甲状腺功能性减退症与不孕症相关性研究进展

doi:10.3969/j.issn.1674-490X.2016.05.012

医学研究与教育 ›› 2016, Vol. 33 ›› Issue (5): 53-58.DOI: 10.3969/j.issn.1674-490X.2016.05.012

甲状腺功能性减退症与不孕症相关性研究进展

常亚清,孔红芳,王凤暖,辛虹

河北医科大学二医院, 河北石家庄 050000

收稿日期:2016-07-11 出版日期:2016-10-25 发布日期:2016-10-25
通讯作者: 辛虹(1962—),女,河北石家庄人,主任医师,博士,博士生导师,主要从事妊娠期合并症等研究。E-mail: xh_hbyd@163.com
作者简介:常亚清(1989—),女,河北威县人,在读硕士,主要从事妊娠期合并症研究。通信作者:辛虹(1962—),女,河北石家庄人,主任医师,博士,博士生导师,主要从事妊娠期合并症等研究。 E-mail: xh_hbyd@163.com

Advances on the study of the relationship between hypothyroidism and infertility

CHANG Yaqing,KONG Hongfang,WANG Fengnuan,XIN Hong

The Second Hospital of Hebei Medical University, Shijiazhuang 050000, China

Received:2016-07-11 Online:2016-10-25 Published:2016-10-25

摘要/Abstract

摘要： 近年来,女性不孕症的患病率逐年升高,研究表明其与性腺轴及性激素的调节作用有关。而甲状腺疾病一直以来都备受关注,它是育龄期女性第二常见的内分泌疾病,其中甲状腺功能减退及相关的甲状腺功能异常在临床中最为常见。随着对这两种疾病及激素研究程度的不断深入,加深了对两者间相关性认识。当甲状腺调节轴及相关激素水平发生变化后,随之影响性腺轴的调节以及卵巢功能,导致性激素水平在一定程度上相应地发生改变。可见,甲状腺激素、性激素、甲状腺轴以及性腺轴之间的相互关系在正常妊娠过程起着至关重要的作用。对甲状腺功能减退及相关的甲状腺功能异常与不孕症之间的相关性的研究进展进行综述。

关键词: 甲状腺功能性减退, 不孕, 甲状腺素, 雌激素

Abstract: In recent years,the incidence of female infertility is increasing,studies have shown that it is closely related to the regulation of gonad axis and sex hormones.Thyroid disease has long been a concern,it is the second most common endocrine disorders in women of childbearing age,including hypothyroidism and thyroid dysfunction related which is the most common in clinical.With the deepening of the study of these two diseases and related hormones,the correlation between the two is deepened.When the thyroid gland axis and related hormone levels changed,the gonad axis and the regulation of ovarian function are going to be affected,causing a corresponding change of the sex hormone levels to a certain extent.Consequently,the relationship between thyroid hormone,sex hormone,thyroid axis and gonad axis plays an important role in normal pregnancy process.The progresses of researches about the correlation between hypothyroidism and thyroid dysfunction related and infertility are summarized.

Key words: hypothyroidism, infertility, thyroid hormone, estrogen

中图分类号:

常亚清,孔红芳,王凤暖,辛虹. 甲状腺功能性减退症与不孕症相关性研究进展[J]. 医学研究与教育, 2016, 33(5): 53-58.

CHANG Yaqing,KONG Hongfang,WANG Fengnuan,XIN Hong. Advances on the study of the relationship between hypothyroidism and infertility[J]. Medical Reserch and Education, 2016, 33(5): 53-58.

参考文献

[1] THOMA M E,MCLAIN A C,LOUIS J F,et al.Prevalence of infertility in the United States as estimated by the current duration approach and a traditional constructed approach[J].Fertil Steril,2013,99(5):1324-1331.e1.DOI:10.1016/j.fertnstert.2012.11.037.
[2] MEDENICA S,NEDELJKOVIC O,RADOJEVIC N,et al.Thyroid dysfunction and thyroid autoimmunity in euthyroid women in achieving fertility[J].Eur Rev Med Pharmacol Sci,2015,19(6):977-987.
[3] KENNEDY R L,MALABU U H,JARROD G,et al.Thyroid function and pregnancy:before,during and beyond[J].J Obstet Gynaecol,2010,30(8):774-783.DOI:10.3109/01443615.2010.517331.
[4] ALAVI A,ADABI K,NEKUIE S,et al.Thyroid dysfunction and autoantibodies association with hypertensive disorders during pregnancy[J].J Pregnancy,2012,2012:742695.DOI:10.1155/2012/742695.
[5] 辛虹.妊娠期甲状腺功能亢进与减退[J].医学研究与教育,2011,28(4):1-8.
[6] 王吉耀,廖二元,黄从新,等.八年制内科学[M].2版.北京:人民卫生出版社,2014.
[7] GRONOWSKI A M,HADDOW J,KILPATRICK S,et al.Thyroid function during pregnancy:who and how should we screen?[J].Clin Chem,2012,58(10):1397-1401.DOI:10.1373/clinchem.2012.185017.
[8] POPPE K,VELKENIERS B,GLINOER D.Thyroid disease and female reproduction[J].Clin Endocrinol(Oxf),2007,66(3):309-321.DOI:10.1111/j.1365-2265.2007.02752.x.
[9] REID S M,MIDDLETON P,COSSICH M C,et al.Interventions for clinical and subclinical hypothyroidism pre-pregnancy and during pregnancy[J].Cochrane Database Syst Rev,2013,5:CD007752.DOI:10.1002/14651858.CD007752.pub3.
[10] DURAN B,OZLU T,KOC O,et al.Relationship of thyroid hormone levels and thyroid autoantibodies with early pregnancy loss and infertility[J].J Obstet Gynaecol,2013,33(8):862-864.DOI:10.3109/01443615.2013.817983.
[11] WEISS R V,CLAPAUCH R.Female infertility of endocrine origin[J].Arq Bras Endocrinol Metabol,2014,58(2):144-152.
[12] KRASSAS K P,GLINOER A D.Thyroid Function and Human Reproductive Health[J].Endocr Rev,2010,31(5):702-755.
[13] COLICCHIA M,CAMPAGNOLO L,BALDINI E,et al.Molecular basis of thyrotropin and thyroid hormone action during implantation and early development[J].Hum Reprod Update,2014,20(6):884-904.DOI:10.1093/humupd/dmu028.
[14] AL KNE.Thyroid disorders and fertility[J].Int J Res Med Sci,2015,3(6):1299-1304.
[15] GABERE K,ZALETEL K,SCHWETZ V,et al.Mechanisms in endocrinology:thyroid and polycystic ovary syndrome[J].Eur J Endocrinol,2015,172(1):R9-R21.DOI:10.1530/EJE-14-0295.
[16] UNUANE D,TOURNAYE H,VELKENIERS B,et al.Endocrine disorders & female infertility[J].Best Pract Res Clin Endocrinol Metab,2011,25(6):861-873.DOI:10.1016/j.beem.2011.08.001.
[17] FUMAROLA A,GRANI G,ROMANZI D,et al.Thyroid function in infertile patients undergoing assisted reproduction[J].Am J Reprod Immunol,2013,70(4):336-341.DOI:10.1111/aji.12113.
[18] VALDIVIELSO C L.Screening for thyroid disease in pregnancy[J].Endocrinol Nutr,2016,63(6):311-312.DOI:10.1016/j.endonu.2015.12.002.
[19] SOWINSKI J,SAWICKA-GUTAJ N,GUTAJ P,et al.The role of free triiodothyronine in pathogenesis of infertility in levothyroxine-treated women with thyroid autoimmunity - a preliminary observational study[J].Gynecol Endocrinol,2015,31(2):116-118.DOI:10.3109/09513590.2014.964200.
[20] SURKS M I,ORTIZ E,DANIELS G H,et al.Subclinical thyroid disease:scientific review and guidelines for diagnosis and management[J].JAMA,2004,291(2):228-238.DOI:10.1001/jama.291.2.228.
[21] CIGNINI P,CAFA E V,GIORLANDINO C,et al.Thyroid physiology and common diseases in pregnancy:review of literature[J].J Prenat Med,2012,6(4):64-71.
[22] CANARIS G J,MANOWITZ N R,MAYOR G,et al.The Colorado thyroid disease prevalence study[J].Arch Intern Med,2000,160(4):526-534.
[23] FITZPATRICK D L,RUSSELL M A.Diagnosis and management of thyroid disease in pregnancy[J].Obstet Gynecol Clin North Am,2010,37(2):173-193.DOI:10.1016/j.ogc.2010.02.007.
[24] YOSHIOKA W,AMINO N,IDE A,et al.Thyroxine treatment may be useful for subclinical hypothyroidism in patients with female infertility[J].Endocr J,2015,62(1):87-92.DOI:10.1507/endocrj.EJ14-0300.
[25] PFEIFER S,BUTTS S,DUMESTIC D,et al.Subclinical hypothyroidism in the infertile female population:a guideline[J].Fertil Steril,2015,104(3):545-553.DOI:10.1016/j.fertnstert.2015.05.028.
[26] ABALOVICH M,MITELBERG L,ALLAMI C,et al.Subclinical hypothyroidism and thyroid autoimmunity in women with infertility[J].Gynecol Endocrinol,2007,23(5):279-283.DOI:10.1080/09513590701259542.
[27] BART'AKOV'A J,POTLUKOV'A E,ROGALEWICZ V,et al.Screening for autoimmune thyroid disorders after spontaneous abortion is cost-saving and it improves the subsequent pregnancy rate[J].BMC Pregnancy Childbirth,2013,13:217.DOI:10.1186/1471-2393-13-217.
[28] GRASSI G,BALSAMO A,ANSALDI C,et al.Thyroid autoimmunity and infertility[J].Gynecol Endocrinol,2001(15):389-396.
[29] MONTELEONE P,PARRINI D,FAVIANA P,et al.Female infertility related to thyroid autoimmunity:the ovarian follicle hypothesis[J].Am J Reprod Immunol,2011,66(2):108-114.DOI:10.1111/j.1600-0897.2010.00961.x.
[30] ARTINI P G,UCCELLI A,PAPINI F,et al.Infertility and pregnancy loss in euthyroid women with thyroid autoimmunity[J].Gynecol Endocrinol,2013,29(1):36-41.DOI:10.3109/09513590.2012.705391.

甲状腺功能性减退症与不孕症相关性研究进展

Advances on the study of the relationship between hypothyroidism and infertility

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