Spinal cord injury is a severe disorder of the central nervous system. The first injury directly damages tissue. Then these secondary problems, such as inflammation, oxidative stress, and poor nerve regeneration, lead to the loss of motor and sensory function in patients. Metal ions play essential roles in biological systems. Among them, zinc ions has attracted growing attention for its neuroprotective potential after the spinal cord injury. Zinc ions regulate multiple signaling pathways to reduce the severity of primary and secondary damage and promote neural function recovery. This review systematically summarizes recent research progress on zinc ions in the field of spinal cord injury, covering mechanisms of action, and therapeutic strategies. The goal of this review is to provide a theoretical basis and reference for their clinical translation and application.

Against the epidemiological backdrop of the intensifying global population aging, various aesthetic changes caused by skin aging and their impact on quality of life have become research hotspots in the fields of dermatology and aesthetic medicine. Ginsenosides, as the core pharmacodynamic material basis of Panax plants, exhibit significant biological activities in delaying skin aging and repairing photo-damage. This paper systematically reviews the multi-target anti-aging mechanisms of ginsenosides. Furthermore, addressing the bottleneck of the low bioavailability of natural ginsenosides, it focuses on analyzing the biotransformation of rare ginsenosides and the application potential of novel transdermal delivery systems, aiming to provide a scientific basis for the development of high-efficacy ginsenoside-based skincare products.

Myocardial bridging(MB)is a congenital coronary artery running abnormality, which refers to the anatomical phenomenon that part of the coronary artery should normally run in the pericardium instead “grows”below the myocardial fiber. MB compression during coronary systolic may cause myocardial ischemia, coronary spasm, arrhythmia, and even sudden death. This article provides an in-depth review of the latest research progress of MB in terms of epidemiology, clinical manifestations, disease physiology, evaluation methods and treatment. Among the three commonly used MB detection methods of CCTA, CAG and IVUS, the detection rate of CAG is the lowest compared with the autopsy research results. MB patients are usually asymptomatic. In clinical diagnosis and treatment, it is often difficult to judge whether the patient's symptoms are related to MB. When identifying the cause, it is necessary to comprehensively consider whether the symptoms are directly related to MB or whether the complications such as coronary spasm and atherosclerotic coronary artery disease caused by MB are indirectly related to MB. MB may cause endothelial dysfunction by changing the hemodynamics of the coronary artery as a whole. There are two types of MB evaluation methods: invasive and non-invasive examination. The former includes coronary angiography, intravascular ultrasound, optical coherence tomography(OCT), coronary artery doppler FFR and iFR, etc. The latter includes coronary artery coronary computed tomography angiography(CCTA), composite echocardiography, myocardial perfusion imaging and electrocardiography, etc. Beta receptor blockers and calcium channel blockers are the first choice for drug treatment of patients with symptomatic MB, which relieve symptoms by reducing myocardial contractility. For drug-intractable MB, interventional treatment and MB lysis can be used, but their long-term efficacy and safety still need to be verified through large-scale research. In the future, MB-related research should focus on the physiological mechanism of the disease and establish a more comprehensive and scientific clinical typing system; multi-center research should be carried out to improve the shortcoming of the overall sample size of relevant research. It should be combined with the technical advantages in the fields of cardiovascular diseases, imaging, biological engineering and artificial intelligence, through the anatomy, function of MB The integration of energy, treatment and prognosis data improves the clinical management level of MB-related diseases.

Objective To analyze the value of aEEG score combined with lactate(Lactic acid)level and absolute count of nucleated red blood cells(NRBC)in peripheral blood for early diagnosis of brain injury in preterm infants.Methods A total of 207 preterm infants born in the Obstetrics Department, Affiliated Hospital of Hebei University and admitted to the neonatal intensive care unit from February 2022 to April 2025 were selected as the research subjects. Subjects were stratified into a brain injury group(n=80)and a non-brain injury group(n=127)based on cranial magnetic resonance imaging(MRI)results.The general data, total aEEG score, lactate level, and absolute counts of NRBC on day 1 and day 3 after birth were compared between the two groups. Results The total aEEG score in the brain injury group was ［6.00(5.00, 7.00)］, lower than that ［7.00(8.00, 9.00)］in the non-brain injury group. The lactic acid level in the brain injury group was ［2.95(2.20, 4.85)］, higher than that ［1.90(1.40, 2.50)］in the non-brain injury group. The absolute count of NRBC on the 1st day after birth in the brain injury group was ［1.12(0.44, 2.29)］, higher than that ［0.39(0.26, 0.79)］ in the non-brain injury group(P<0.05).Logistic regression analysis showed that the higher aEEG score was a protective factor for brain injury in preterm infants(P<0.05), while higher lactate levels and absolute count of NRBC on day 1 after birth were risk factors for brain injury(P<0.05). ROC curve analysis showed that the areas under the curve(AUC)for single evaluation of brain injury by total aEEG score, lactate level, and absolute count of NRBC on day 1 after birth were 0.826, 0.797, and 0.737 respectively. The combined prediction of the three indicators achieved an AUC of 0.892. Conclusion The combination of aEEG score, lactate level, and absolute count of NRBC in peripheral blood can boost early diagnostic accuracy and efficiency for brain injury in preterm infants, providing a reference for clinical intervention.

Objective To evaluate the clinical efficacy and safety of ultrapulsed fractional CO₂ laser combined with photorejuvenation for the treatment of facial atrophic acne scars.Methods Sixty patients with acne scars from the Department of Dermatology, Affiliated Hospital of Hebei University were randomly assigned to a CO₂ laser group and a combination treatment group, with 30 patients in each. The CO₂ laser group received ultrapulsed fractional CO₂ laser treatment once every 3 months for a total of 5 sessions. The combination treatment group received the same ultrapulsed fractional CO₂ laser treatment, and one month after each laser session, photorejuvenation treatment was added, completing a total of 5 combined treatment cycles.Results The marked improvement rate in the combination group(70.00%)was significantly higher than that in the CO₂ laser group(36.67%)(P=0.011), and the combination therapy demonstrated superior pain relief(P=0.007). Subgroup analysis showed that the combination approach led to greater improvement of icepick and rolling scars compared with the control group. The total effective rate exceeded 90% in both groups, and no serious adverse events were observed.Conclusion Ultrapulsed fractional CO₂ laser combined with photorejuvenation is a safe and effective treatment strategy, particularly suitable for icepick and rolling types of atrophic acne scars.

Tradition Chinese medicine(TCM)textbooks are important physical evidence of TCM education, which can reflect the level of TCM education to a certain extent.After the liberation of Hebei province, the education of traditional Chinese medicine in colleges and universities was among the best in China, and the early compilation of TCM textbooks was actively explored and successful experience was accumulated.By collecting physical materials and consulting the textbooks and notes kept by the students, such as Jiang Jinjian, Guo Xianmin, Deng Wenli, Sun Dasan, Li Xiufu, etc,the author makes a textual research on the early TCM textbooks in Hebei province.The early TCM textbooks experienced two periods: Hebei Provincial School for Advanced Study of Traditional Chinese Medicine and Hebei College of Traditional Chinese Medicine, two types as handouts and experience exchange, five stages.Through the textual research on the evolution of the early TCM textbooks in Hebei province, we hope to provide a useful reference for the development of TCM education.

Objective To investigate the differences of verbal working memory and event-related potentials in nursing undergraduates with different test anxiety levels and provide a neurophysiological basis for training verbal working memory to reduce test anxiety. Methods 77 first-year nursing students from a comprehensive university in Hebei province were selected as the study subjects, and test anxiety scale (TAS)was used to assess the test anxiety of 77 nursing undergraduates. According to the evaluation results, nursing undergraduates with TAS≤12 points were selected as the low test anxiety group(n=48), while nursing undergraduates with TAS≥20 points were selected as the high test anxiety group(n=29). Independent sample t test was used to compare the differences between verbal working memory span, P300 latency and amplitude between the two groups. Results Participants in the low test anxiety group exhibited significantly higher scores on both the reading span and counting span tasks compared with those in the high test anxiety group(P<0.05). In contrast, the high test anxiety group demonstrated a significantly longer reaction latency than that of the low test anxiety group(P<0.05). Moreover, the amplitude at the Cz electrode was markedly greater in the high test anxiety group relative to the low anxiety group(P<0.05). However, no significant group differences were observed in the amplitudes at Fz or Pz(P>0.05). Conclusion Nursing students with high levels of test anxiety show poorer verbal working memory performance, require more time to evaluate and categorize stimuli, and invest greater mental effort during the updating of working memory representations compared with those in the low-anxiety group. Attention deficit may be the main cause of exam anxiety. Future research can reduce test anxiety by strengthening attention bias training, working memory training and mindfulness training to increase attention control ability.

Objective To explore the effectiveness of traditional Chinese medicine compress combined with specific electromagnetic wave(TDP)irradiation and nursing intervention in improving hand symptoms in patients with systemic sclerosis(SSc)during clinical management. Methods A total of 122 hospitalized patients diagnosed with SSc at Hebei Yiling Hospital from August 2023 to March 2025 were randomly divided into a control group and a research group using a random number table method, with 61 cases in each group. The control group received routine nursing intervention, while the research group received traditional Chinese medicine compress combined with TDP irradiation in addition to the routine nursing intervention. The treatment response rate, Raynaud phenomenon(RP)activity, hand function, pain degree, quality of life, and Taylor-Pelmear stage changes were observed and compared between the two groups.Results After 3 weeks of treatment, the efficacy in the research group was superior to that in the control group(P=0.038). There were no statistically significant differences in RP activity, hand function, pain degree, quality of life, and Taylor-Pelmear stage between the two groups before intervention(P>0.05). After 3 weeks of treatment, the Raynaud Severity Score(RS)in the research group was lower than that in the control group(P<0.05), the fist-clenching test time was shorter than that in the control group(P<0.05), and the Pain Visual Analog Scale(VAS)score was lower than that in the control group(P<0.05). The quality of life scores increased in both groups, and the research group was superior to the control group(P<0.05). The Taylor-Pelmear stage significantly improved in both groups, and the improvement in the research group was better than that in the control group(P<0.05). Conclusion In the clinical management of patients with SSc, traditional Chinese medicine compress combined with TDP irradiation and nursing intervention can effectively improve hand symptoms, significantly alleviate RP, reduce pain, promote hand function recovery, improve quality of life, and demonstrate good safety.