The experimental research and clinical application prospect of ischemic postconditioning in brain ischemia

doi:10.3969/j.issn.1674-490X.2014.04.018

Abstract

Abstract: Ischemic postconditioning is a concept originally defined to contrast with that of ischemic preconditioning. While both preconditioning and postconditioning confer a neuroprotective effect on brain ischemia, preconditioning is a sublethal insult performed in advance of brain ischemia, and postconditioning, which conventionally refers to a series of brief occlusions and reperfusions of the blood vessels, is conducted after ischemia/reperfusion. In recent years, extensive studies show that postconditioning has apparently protective effects. We mainly review the discovery and development, the underlying mechanisms and clinical application of it.

Key words: ischemic postconditioning, cerebral ischemia, neuroprotection, ischemic preconditioning

CLC Number:

LI Pan,SU Likai,LI Xiaofang. The experimental research and clinical application prospect of ischemic postconditioning in brain ischemia[J]. Medical Reserch and Education, 2014, 31(4): 75-80.

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