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Medical Reserch and Education    2018, 35 (1): 7-12.   DOI: 10.3969/j.issn.1674-490X.2018.01.002 Abstract （2149）      PDF（pc） （1072KB）（1698）       Knowledge map    Save Hospice care have been covered in medical service system in many countries across the world. China has a big demand for hospice care and currently starts to advocate the principles of hospice and develop programs of hospice in practice. The history,development and current status of hospice care worldwide are described,and the developmental prospect of hospice care in China in terms of enhancing top-level design,improving medical insurance, and establishing Hospice care service system are also discussed. Reference | Related Articles | Metrics | Comments（0）

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Medical Reserch and Education    2019, 36 (4): 52-58.   DOI: 10.3969/j.issn.1674-490X.2019.04.010 Abstract （1633）      PDF（pc） （462KB）（476）       Knowledge map    Save Life and death education in hospice care is very important. It is one of the important indicators of the quality of death, which can reduce the fear of patients, help patients' families increase the courage to face bereavement, promote the growth of medical staff and improve the relationship between doctors and patients. To do life and death education, hospice care workers should have good life and death quality. To do life and death education in hospice care, we should first remove the barriers of life and death education in hospice care and learn how to tell bad news. Life and death education for patients and their families includes listening, holding workshops, workshops and administering dignity therapy. Hospice care also needs to fully explore life and death education resources, including human resources, cultural resources, academic resources and social resources. Reference | Related Articles | Metrics | Comments（0）

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Medical Reserch and Education    2019, 36 (3): 15-18.   DOI: 10.3969/j.issn.1674-490X.2019.03.003 Abstract （1619）      PDF（pc） （380KB）（380）       Knowledge map    Save Objective To compare and evaluate the effectiveness of four methods of intubation in isolated frog heart perfusion. Methods Isolated frog heart specime were prepared by Straub method, BAMU-HARTUNG'S method, right aortic intubation and posterior vena cava+left aorta intubation method, to analyze the differences of four methods in the time of cannulation, time of heart ex vivo, successful rate, survival rate, heart survival time and rate of coagulation. Results Compared with the traditional intubation-Straub method, the two kinds of double-cannula method were increased in the successful rate, survival rate and heart survival time, decreased in the rate of coagulation, and there were significant difference(P＜0.05),but increased in the time of cannulation and isolated heart, and there were significant difference(P＜0.05). Compared with Straub method, right aortic intubation was increased in the successful rate, survival rate and heart survival time, decreased in coagulation rate and the time of cannulation, and there were significant difference(P＜0.05).But the time of isolated heart was no significant difference(P＞0.05). Compared with the two kinds of double-cannula method, right aortic intubation was decreased in successful rate, the time of cannulation and isolated heart, increased in coagulation rate,and there were significant difference(P＜0.05), but heart survival time and survival rate had no significant difference(P＞0.05).Conclusion The comprehensive evaluation showed that the right aortic intubation method had a great advantage in the isolated frog heart perfusion experiment. Reference | Related Articles | Metrics | Comments（0）

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Comparison of increase of the dose of cisatracurium and rocuronium on the onset time and the clinical duration WU Yi,LI Yongle,WANG Hongjie Medical Reserch and Education    2014, 31 (4): 23-26.   DOI: 10.3969/j.issn.1674-490X.2014.04.006 Abstract （1394）      PDF（pc） （1413KB）（700）       Knowledge map    Save Objective To study the effects of the increase of the dose of cisatracurium and rocuronium on the onset time and the clinical duration. Methods 120 patients ASAⅠ-Ⅱ, aged 30-55 years, scheduled for elective gynecologic surgery were randomly divided into four groups(n=30). Group A received cisatracurium 0.10 mg/kg(2×ED95). Group B received cisatracurium 0.15 mg/kg (3×ED95). Group C received cisatracurium 0.2 mg/kg(4×ED95). Group D received rocuronium 0.9 mg/kg. Neuromuscular block was monitored by a TOF Watch SX accelerograph. The onset time and the clinical duration were recorded. Results The onset times for group A, B, C and D were (226±57)s, (184±56)s, (135±45)s, (80±25)s seconds respectively. Compared with group A, B, D, there was statistically difference between group C and those groups (P<0.05). The clinical effective time were (33±5)min, (41±8)min, (53±8)min, (42±11)min among group A, B, D, respectively, compared with group A, B, D, there were signiifcant difference between group C and those groups (P<0.05).Conclusion Increasing dose could signiifcantly shorten cisatracurium onset time of intubation. But compared with rocuronium, clinical duration is longer. Cisatracurium is not suitable for short surgical operation. The clinical effects of rocuronium time variability controllability, cisatracurium is better than that of rocuronium. Reference | Related Articles | Metrics | Comments（0）

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Common alarm analysis and treatment of ventilator WANG Xinping, CAO Guohui Medical Reserch and Education    2015, 32 (1): 70-75.   DOI: 10.3969/j.issn.1674-490X.2015.01.017 Abstract （1288）      PDF（pc） （902KB）（3022）       Knowledge map    Save Mechanical ventilation is an effective means of life support and respiratory therapy, has been widely applied in clinic fields. Especially in recent years, the construction of the emergency in two level of first-class hospital and ICU established, ventilator applications gain popularity. Ventilator alarm is a frequent problem in mechanical ventilation, if handled improperly, not only affect the ventilator’s using, but also endanger the patient's life. So correct judgment and timely remove alarm is very important. Clinical medical staff who are not very familiar with ventilator application will feel the tension and pressure on ventilator alarm, even feel be at a loss, they can not be quickly make sure the reasons and perform the correct treatment .This paper analyzes the reasons of ventilator alarm in order to help doctors and nurses to handle the common reasons ,and further improve the success rate of resuscitation of critically ill patients. Reference | Related Articles | Metrics | Comments（0）

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Medical Reserch and Education    2018, 35 (6): 65-68.   DOI: 10.3969/j.issn.1674-490X.2018.06.012 Abstract （1188）      PDF（pc） （372KB）（225）       Knowledge map    Save Objective To explore a method of exchanging double-J stent in special cases(such as the patients with severe cystitis glandularis who are difficult to find ureteral orifice). Methods We retrospectively analyzed twenty patients with ureteral obstruction caused by different causes that all needed to exchange with a total of 25 double-J stents,15 stents on the left sides and 10 stents on the right sides. The original double-J stent was carefully pulled out to the external urethral orifice, then inserted into the renal pelvis along the orifice of the double-J stent, the old double-J stent was pulled out. And then the new double-J stent was placed along the guide wire. Results 24 of 25 double-J stents in 20 patients were inserted successfully without perforation and hemorrhage. There was a complication of bladder mucosal bleeding in one case. Conclusion This method can reduce the difficulty of intubation and ensure success. Reference | Related Articles | Metrics | Comments（0）

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Medical Reserch and Education    2018, 35 (1): 54-57.   DOI: 10.3969/j.issn.1674-490X.2018.01.011 Abstract （1111）      PDF（pc） （928KB）（573）       Knowledge map    Save Objective To observe the clinical curative effect of Suliao acupoint bloodletting and ultraviolet radiation in the treatment of allergic rhinitis.Methods 156 cases of allergic rhinitis patients treated from February 2013 to September 2015 were selected as subjects,the patients were randomly divided into two groups,78 cases each.The treatment group was used Suliao acupoint bloodletting combined with ultraviolet therapy,the control group was treated with ultraviolet therapy.10 days as 1 treatment courses.The clinical efficacy of two groups and two groups of patients with runny nose,sneezing,nasal itching,nasal congestion improvement time were observed and compared.Results The total effective rate was 80.77% in the treatment group and 66.67% in the control group,and the difference was statistically significant(P<0.05).Runny nose,sneezing,nasal itching,nasal obstruction improved time in the patients in the treatment group were significantly better than that of the control group(P<0.05).Conclusion The treating effects of Suliao acupoint bloodletting combined with ultraviolet treatment of allergic rhinitis is significant,which is worthy of distribution in clinical practices. Reference | Related Articles | Metrics | Comments（0）

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Medical Reserch and Education    2020, 37 (1): 20-25.   DOI: 10.3969/j.issn.1674-490X.2020.01.004 Abstract （1082）      PDF（pc） （401KB）（264）       Knowledge map    Save Objective To observe therapeutic effect and metabolism of blood lipid with Ginkgo leaves tablet and olanzapine on schizophrenia.Methods 80 schizophrenics were randomly divided into two groups:single grouptreated with olanzapine alone(15±5)mg/d, combination group on the basis of olanzapine(15±5)mg/d, and with ginkgo leaves tablet 1.2g/d. The treatment lasted for 8 weeks. Before treatment and at the end of the 2nd, 4th and 8th week, the concentrations of triglyceride(TG), the total cholesterol(TC), low density lipoprotein(LDL)and high density lipoprotein(HDL)of the two groups were monitored. Results In the single group, TG, TC and LDL at 4 weeks and 8 weeks were significance higher than those before treatment(P<0.05), the HDL were significance lower than those before treatment(P<0.05). In the combined group, the LDL and HDL had no significant change compared with those before treatment(P>0.05), the TG and TC were significance higher than those before treatment(P<0.05). Interesting, the TG and TC of the combined group were significance lower than the single group at the 8th weeks(P<0.05). Conclusion The patients with schizophrenia who take olanzapine often have the change of blood lipid level in different degrees, and Ginkgo leaves tablet can antagonize the increase of blood lipid, which is better than that of olanzapine alone. Reference | Related Articles | Metrics | Comments（0）

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Journal of Hebei Medical College for Continuing Education    2021, 38 (4): 29-33.   DOI: 10.3969/j.issn.1674-490X.2021.04.005 Abstract （1018）      PDF（pc） （483KB）（107）       Knowledge map    Save Objective To explore the therapeutic effect of Kangfuxin solution external application in the treatment of facial hormone-dependent dermatitis. Methods A total of 96 patients with hormone-dependent dermatitis were collected in the outpatient department. Of those, 48 patients were given a local cold compress with Kangfuxin solution and the others were given a cold compress with normal saline. The treatment effects of the two groups were compared. Results Through the comparison and analysis of the scores of the two groups, the difference in scores at different times was statistically significant(F=16.340, P<0.001), and the difference between the two groups was statistically significant(F=12.785, P<0.001).The score of Kangfuxinye group was significantly higher than that of normal saline group. Of the 48 patients in the Kangfuxinye group, 39 were cured, 8 cases were markedly effective, and 1 case improved; in the normal saline group, 36 cases were cured, 10 cases were markedly effective, and 2 cases improved. There was no statistically significant difference in efficacy between the two groups(Z=0.765, P>0.05). The recurrence rates observed in the Kangfuxinye group were 4.17%, 6.25%, and 10.42% at 1 month, 3 months, and 6 months after treatment; and the recurrence rates of the normal saline group were: 18.75%, 25.00%, and 35.42%. The difference in recurrence rate was statistically significant(P<0.05)between these two groups.Conclusion Kangfuxin solution has a good effect in the treatment of hormone-dependent dermatitis and can reduce the recurrence of the disease. Reference | Related Articles | Metrics | Comments（0）

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Medical Reserch and Education    2019, 36 (2): 1-7.   DOI: 10.3969/j.issn.1674-490X.2019.02.001 Abstract （1015）      PDF（pc） （446KB）（426）       Knowledge map    Save Atherosclerosis(AS)is a chronic inflammatory disease caused by an imbalance in lipid metabolism and an adaptive immune response driven by the accumulation of cholesterol-containing macrophages in the arterial wall. In recent years, research on the mechanism of AS mainly includes lipid hypothesis, inflammation hypothesis and so on. This review mainly summarizes the mechanism of AS in recently years and briefly discusses the drug treatment of AS. Reference | Related Articles | Metrics | Comments（0）

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Journal of Hebei Medical College for Continuing Education    2021, 38 (2): 1-7.   DOI: 10.3969/j.issn.1674-490X.2021.02.001 Abstract （1007）      PDF（pc） （914KB）（551）       Knowledge map    Save Objective To provide a reliable primary hepatocyte steatosis cell model for the pathogenesis, prevention and treatment of non-alcoholic fatty liver disease(NAFLD).Methods Primary mouse hepatocytes were isolated by Seglen two-step perfusion method and its improved method.After cultured in vitro for 48 hours, different concentrations of free fatty acid(FFA)mixture ［oleic acid(OA)∶palmitic acid(PA)=2∶1］ were induced for 24 hours.The lipid droplet deposition in hepatocytes was observed by oil red O staining and the content of triglyceride(TG)in cells was determined by automatic biochemical analyzer.Results Compared with the control group, there were red lipid droplets in hepatocytes in the model group, and the concentration of FFA mixture was dose-dependent, and the content of TG in hepatocytes in the model group was significantly higher than that in the control group(P<0.05), and increased with the increase of the concentration of FFA, suggesting that the lipid deposition in hepatocytes increased with the increase of FFA concentration.Conclusion The primary hepatocyte steatosis cell model is successfully established, which provides a reliable cell model for the study of non-alcoholic fatty liver disease. Reference | Related Articles | Metrics | Comments（0）

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Challenges and countermeasures of population aging to public health service CHENG Huaizhi, GUO Bin, SONG Jiawei, LI Yu Journal of Hebei Medical College for Continuing Education    2022, 39 (1): 49-53.   DOI: 10.3969/j.issn.1674-490X.2022.01.007 Abstract （998）      PDF（pc） （430KB）（282）       Knowledge map    Save China is facing a huge medical challenge from its aging problem. By 2050, China's population aged 65 and above will reach 400 million, of which the population aged 80 and above will reach 150 million. This paper reviews the evolution and current situation of population aging systematically through literature review, and analyzes some public health problems caused by China's aging population from the perspective of economic: underutilization of health service, the rapid rise of health costs, the huge demand for nursing service. It is suggested that we should strengthen health education for the elderly, expand nursing service, provide individual nursing care for them, further improve the medical security system and build a sustainable long-term care insurance system. Reference | Related Articles | Metrics | Comments（0）

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Effects of peony licorice bolus of risperidone with different proportions on female schizophrenia patients suffered hyperprolactinemia XIE Shanshan, DING Liang, CHEN Yaqing Medical Reserch and Education    2015, 32 (5): 35-38.   DOI: 10.3969/j.issn.1674-490X.2015.05.009 Abstract （927）      PDF（pc） （538KB）（651）       Knowledge map    Save Objective To observe the effects of peony licorice bolus of risperidone with different proportions on female schizophrenia patients suffered hyperprolactinemia induced by risperidone. Methods 120 patients were randomly divided into group A (Risperidone), group B (Peony∶licorice 1∶1, Risperidone), group C (Peony∶ licorice 2∶1, Risperidone). The change of serum levels of prolactin, estradiol, testosterone, follicle stimulating hormone, luteinizing hormone, progesterone were observed before and after treatment for 4, 8 and 12 weeks. Positive and negative symptom scale were used to evaluate the effect of treatment before and after treatment. Adverse drug reactions were evaluated by using the side reaction scale before and after treatment. Results Compared with group B and group C, the serum of prolactin levels of group A were significantly decreased (P<0.05). Compared with group B, the serum of prolactin levels of group C were significantly decreased (P<0.05), which suggested that the serum levels of prolactin in female patients with schizophrenia could be reduced by a greater degree than 2∶1 that of 1∶1. Conclusion The peony and licorice pill can obviously reduce serum prolactin levels of risperidone, but the ratio is 2∶1 to the maximum extent of the serum prolactin levels of the peony and licorice pills. Reference | Related Articles | Metrics | Comments（0）

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Journal of Hebei Medical College for Continuing Education    2020, 37 (6): 7-13.   DOI: 10.3969/j.issn.1674-490X.2020.06.002 Abstract （913）      PDF（pc） （400KB）（615）       Knowledge map    Save Coxsackievirus A group 16 strain(CA16)infection is very common in China. CA16 constantly mutated in the epidemic process, and its pathogenicity is significantly different from enterovirus 71(EV71). CA16 can induce a variety of microRNAs(miRNAs)and affect the transmission of inflammatory signaling pathways, leading to pathological damage. At present, CA16 infection models in mice, tree shrews and macaques have been successfully established, which can be used to evaluate the effect of anti CA16 drugs and vaccines. In terms of detection, multiplex real-time RT-PCR can be used for high-sensitivity detection and rapid typing of HFMD, and colloidal gold immunochromatographic assays can be used for rapid diagnosis. A variety of monovalent and multivalent CA16 vaccines can induce effective immunity in animal experiments. Reference | Related Articles | Metrics | Comments（0）

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Journal of Hebei Medical College for Continuing Education    2020, 37 (4): 60-67.   DOI: 10.3969/j.issn.1674-490X.2020.04.011 Abstract （901）      PDF（pc） （548KB）（620）       Knowledge map    Save By systematically sorting out the CNKI1988—2018 journal literature and taking the extension and change of the research field and research content as the dividing standard, the death education research in China is divided into three stages: starting, comprehensive exploration and in-depth development. That is to say, China's death education research has gone from the development of medical professional response education to universal preventive education to post-disaster psychological disaster education. Over the past three decades, scholars have focused on two basic issues of death education and educational practice, and have reached a basic consensus on the value of death education, the current status of death education in China, and the multi-agent cooperation of death education. At the same time, there are still some shortcomings such as basic theoretical problems, general research perspective, scattered research content, and traditional research methods. In the future, death education research urgently needs to combine the experience of lifelong learning and the integration of “knowledge-prevention-rescue” on the basis of absorbing international experience, relying on China's cultural traditions, and combine multidisciplinary theoretical research and comprehensive practice exploration. Efforts will be made to explore practical implementation strategies for death education, and build a death education system and research system with Chinese characteristics to enhance the pertinence and effectiveness of death education. Reference | Related Articles | Metrics | Comments（0）

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Journal of Hebei Medical College for Continuing Education    2021, 38 (5): 15-19.   DOI: 10.3969/j.issn.1674-490X.2021.05.003 Abstract （872）      PDF（pc） （431KB）（88）       Knowledge map    Save Objective To observe the clinical efficacy and safety of recombinant human interferon α1b nasopharyngeal spray in treatment of viral upper respiratory tract infection. Methods 112 children with viral upper respiratory tract infection diagnosed in pediatric outpatient department of our hospital from April 2018 to December 2020 were collected. According to the random method, they were divided into experimental group and control group, with 56 cases in each group. The experimental group was given 100 U recombinant interferon α1b+2 mL normal saline to spray nasopharynx, with 3 times/d and continuous treatment for 3-5 days. And both groups were given routine treatment such as cough relieving, phlegm resolving, fever reducing and anti-infection. After 3-5 days of treatment, the improvement of symptoms of upper respiratory tract infection, signs(nasal congestion, runny nose, cough, fever, pharyngeal congestion)and adverse reactions were compared between the two groups. Results The duration of fever(t=5.707, P=0.000), remission time of systemic symptoms(t=6.994,P=0.000)total course(t=4.593, P=0.000)of the experimental group were shorter than those of the control group, and the difference was statistically significant. The curative effects of the experimental group were better than the control group(Z=-2.869, P=0.004). The scores of nasal congestion, runny nose(t=14.707, P=0.000), cough(t=13.710, P=0.000)and pharyngeal congestion(t=13.430, P=0.000)in the experimental group were better than those in the control group. Only one child in the experimental group had nausea, and the others had no adverse reactions. Conclusion The application of recombinant human interferon α1b nasopharyngeal spray is effective and safe in the treatment of children with acute upper respiratory tract infection. Reference | Related Articles | Metrics | Comments（0）

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Distribution and biological function of endothelin receptors ZHANG Ke,CHEN Queting,WANG Xiaodong,ZHANG Yue,LI Tingting,SHI Lin Medical Reserch and Education    2014, 31 (3): 76-81.   DOI: 10.3969/j.issn.1674-490X.2014.03.020 Abstract （852）      PDF（pc） （1401KB）（1044）       Knowledge map    Save Endothelins (ETs) are composed of 21-aminoacids produced by endothelial cells and considered to be potent vasoconstrictor. Recent studies found that they could not only induce the angiogenesis, mitosis and differentiation, but also act the role of cytokines. Previous studies have identiifed three isoforms of ET (ET-1, ET-2 and ET-3), which are involved in a variety of physiological and pathological processes. ET-1 is most potent one among ETs, whereas ET-3 is the weakest once. ET peptides exhibit their functions in a number of mammalian physiological systems, including gastrointestinal. ETs act via two distinct isoforms of receptors in human body, i.e. endothelin receptor A (ETA) and endothelin receptor B (ETB), which can be found expressed in many mammalian cardiovascular system, neural system and gastrointestinal tract. ETA and ETB have same signaling pathways. And at the meantime, ETB can promote the activation of PLA2. The study also found that endothelins were widely associated with benign and malignant diseases. Reference | Related Articles | Metrics | Comments（0）

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Medical Reserch and Education    2018, 35 (6): 19-23.   DOI: 10.3969/j.issn.1674-490X.2018.06.004 Abstract （840）      PDF（pc） （493KB）（152）       Knowledge map    Save Objective To observe the effects of magnetic field intervention on the distribution of blood vessels in the scar after peripheral nerve injury in rats. Methods 160 SD rats were divided into 4 groups at random, 40 rats in each group. The experimental rats were made sciatic nerve injury model. Low intensity, medium intensity and high intensity(0.2 mT, 0.6 mT and 1.5 mT)were given to the experimental group for magnetic field intervention with a frequency of 20 Hz and 60 min/d. The rats of the control group were raised normally without treatment. At the 8th week after operation, vascular perfusion and immunohistochemistry were performed to observe the distribution of blood vessels at the nerve scar. Results At 8 weeks after surgery, compared with the control group(P<0.01), the blood vessels in the experimental group were more evenly distributed, more abundant, higher density and more regular vascular shape. Conclusion The magnetic field can change the blood vessel distribution at the nerve scar and improve the blood supply to the nerve tissue at the injury. Reference | Related Articles | Metrics | Comments（0）

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Glutathione S-transferases and its oxidative stress Medical Reserch and Education    2010, 27 (5): 80-83.   DOI: 10.3969/j.issn.1674-490X.2010.05.025 Abstract （809）      PDF（pc） （270KB）（959）       Knowledge map    Save Reference | Related Articles | Metrics | Comments（0）

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Medical Reserch and Education    2020, 37 (1): 71-75.   DOI: 10.3969/j.issn.1674-490X.2020.01.013 Abstract （735）      PDF（pc） （402KB）（162）       Knowledge map    Save In recent years, palliative care under the leadership of the government is gradually rising in mainland China, the convening of academic conferences and the launch of pilot units have all promoted the development of palliative care. Palliative care focus on humanism, psychosocial and spiritual concerns of patients. The curriculum construction and professional education related to palliative care in medical colleges should also reflect the core idea of palliative care. Therefore, it is necessary to set up the related courses of palliative care in medical colleges and as an important part of the professional quality education. Only when medical students learn the knowledge related to palliative care, can they better apply the knowledge to clinical practice. This paper reviews the current status, development and curriculum construction of palliative care in China, and provides reference for the medical education and training of professionals in China. Reference | Related Articles | Metrics | Comments（0）

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Medical Reserch and Education    2019, 36 (6): 48-53.   DOI: 10.3969/j.issn.1674-490X.2019.06.009 Abstract （732）      PDF（pc） （559KB）（195）       Knowledge map    Save Objective To explore the research hotspots and research frontiers in the field of hospice care through the visual analysis of the hospice care literature in the CNKI database for the past 19 years and provide a reference for the research of hospice care. Mothods CiteSpace visual analysis software was used to visualize the collection of 5 221 articles on hospice care, and draw the knowledge maps of authors and institutions,research hotspots and research frontiers. Results The top 5 authors in the field of hospice care research were Shi Yongxing,Wang Yumei,Xu Yan,Yuan Changrong,Shi Baoxin.The top 5 institutions were: Chinese Association for Life Care, The Nursing College of Zhengzhou University, Changzheng Community Health Service Center, Putuo District, Shanghai, Department of Gerontology, Peking Union Hospital, Jilin Medical University.The research topics focus on hospice care, palliative care and care.The research population was mainly dying,cancer and tumor patients.The research direction in the past three years was mainly gastric cancer, hospice care, palliative surgery and community. Conclusion The cooperation in the field of hospice care research is not satisfied enough in China. In the future,we should explore and practice hospice care in the field of cancer and oncology,and also promote it in a wider range, such as community health centers. Reference | Related Articles | Metrics | Comments（0）

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Journal of Hebei Medical College for Continuing Education    2020, 37 (5): 50-54.   DOI: 10.3969/j.issn.1674-490X.2020.05.007 Abstract （729）      PDF（pc） （539KB）（155）       Knowledge map    Save This paper introduces ZHANG Xiangnan's clinical experience in the diagnosis and treatment of dermatosis. ZHANG Xiangnan was born in a family of four generations of traditional Chinese medicine. He was a teacher of Hebei College of Traditional Chinese Medicine. In his later years, he worked in the First Hospital of Baoding(Affiliated Hospital of Hebei University). He served as a famous old Chinese medicine doctor in the last century in Baoding city. In order to inherit the experience of traditional Chinese medicine through collecting and sorting out ZHANG Xiangnan's existing medical books over the years, some experiences which could reflect ZHANG Xiangnan's academic characteristics were selected for references in clinical practices. Reference | Related Articles | Metrics | Comments（0）

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Medical Reserch and Education    2018, 35 (4): 11-18.   DOI: 10.3969/j.issn.1674-490X.2018.03.003 Abstract （707）      PDF（pc） （486KB）（289）       Knowledge map    Save Objective To study the clinical characteristics and the comprehensive diagnosis and treatment of gastroesophageal reflux larynspasm(GERL). Methods GERL patients with characteristics of laryngeal spasm by symptoms questionnaire selected from January 2010 to June 2016 were admitted continuous hospitalization; had excellent response to PPI, antireflux radiofrequency or fundoplication after gastroscopy, manometry and 24 hours pH examination; without laryngeal spasm episodes in follow-up of more than 12 months after antireflux therapy.The gastroesophageal reflux disease(GERD)symptom spectrum, characteristics of larynspasm attack, examination results, and response to antireflux treatment of the GERL patients were statistically analyzed. Results A total of 64 patients with GERL were included in the study, with an average age of 48.9 years. 71.9% of the patients had typical symptoms of GERD such as acid reflux and heartburn, 75% had other extraesophageal reflux symptoms such as cough and asthma. 35.9% of the patients complained regurgitation could cause choking cough and the following larynspasm, 73.4% reported of increased larynspasm episodes after meal, irritating food intake, over eating, or alcohol consumption, and 42.2% complained larynspasm was prone to occure in supine position during sleep. The detecting rates of pathological acid reflux and esophagitis by 24 h pH monitoring and gastroscopy were 53.1% and 48.6%, respectively. 37.5% of the patients had good response, 51.6% had partial response, and 10.9% had poor response to PPI therapy. 84.4% of the patients failed to stop or had no resopse to PPI converted to radiofrequency or fundoplication, and good results were achieved. Conclusion Larynspasm could one of the extraesophageal reflux manifestations of GERD, larynspasm could be combined with typical symptoms and/or extraesophageal symptoms of GERD. Part of the patients’ larynspasm onset is associated with reflux symptoms, diet and body position, which is helpful for the diagnosis of GERL. GERL usually responds well to antireflux therapy such as PPI, radiofrequency and fundoplication. Reference | Related Articles | Metrics | Comments（0）

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Teaching experience of physical diagnostics practice Medical Reserch and Education    2012, 29 (6): 74-78.   Abstract （688）      PDF（pc） （1614KB）（405）       Knowledge map    Save Abstact:Practice teaching is the important component of physical diagnostics. It is the important links to improve the students practice ability and comprehensive quality, meanwhile it is also a preparation for students to enter clinical study. In this article we will discuss how to improve the practice teaching of physical diagnostics from fllowing aspects:deepening the understanding of practice teaching, enhancing teachers team construction, adjusting teaching content, improving teaching methods, strengthening the assessment of practice teaching. Reference | Related Articles | Metrics | Comments（0）

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Medical Reserch and Education    2011, 28 (5): 112-.   DOI: 10.3969/j.issn.1674-490X.2011.05.026 Abstract （686）      PDF（pc） （52KB）（307）       Knowledge map    Save Reference | Related Articles | Metrics | Comments（0）

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Medical Reserch and Education    2018, 35 (3): 26-29.   DOI: 10.3969/j.issn.1674-490X.2018.03.004 Abstract （670）      PDF（pc） （919KB）（413）       Knowledge map    Save Objective To investigate the incidence and influencing factors of fever after modified electroconvulsive therapy in male psychiatric patients.Methods Data of 231 patients with mental disorders who had received and completed modified electroconvulsive therapy in a mental hospital in Beijing, and then gathered data using a self-made date collection table. Results Among the 231 patients, 34 patients had fever(14.72%)after electroconvulsive therapy. Those 34 patients had fever for 53 times in total, low-grade 19 times(35.85%), moderate fever 23 times(43.40%), high fever 11 times(20.75%). After comparing between febrile patients and the non-febrile patients, it found that difference between two variables of age(t=4.007, P<0.01)and course of disease(P=0.016)were statistically significant, and there were statistical differences between different age groups(χ2=20.992, P<0.01).Conclusion Fever will occur in some patients after modified electroconvulsive therapy, especially in patients with small age and short course of disease, and most of them are transient fever, mainly low-fever and moderate fever. Reference | Related Articles | Metrics | Comments（0）

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Medical Reserch and Education    2017, 34 (4): 74-77.   Abstract （660）      PDF（pc） （900KB）（445）       Knowledge map    Save Related Articles | Metrics | Comments（0）

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Medical Reserch and Education    2019, 36 (4): 72-80.   DOI: 10.3969/j.issn.1674-490X.2019.04.013 Abstract （657）      PDF（pc） （647KB）（222）       Knowledge map    Save Objective To explore the current situation of Chinese medicine culture self-confidence of college students of traditional Chinese medicine. Methods Taking the undergraduates of a Chinese medicine university as the research object, 579 undergraduates of a Chinese medicine university were surveyed and analyzed with self-designed questionnaires. The current situation of confidence in traditional Chinese medicine culture and the evaluation of education and teaching strategies were evaluated. The average score of cultural confidence questionnaires was calculated, with the highest score of 5 and the lowest score of 1. Results The average score of Chinese medicine cultural cognition was 3.24 ±0.69, emotion was 4.48±0.58, attitude towards western medicine culture was 4.90±0.60, and related behavior was 4.39±0.84. More than 60% of college students thought that they lack the education of traditional Chinese medicine culture and 73.58%considered that they lack practical teaching. The top three educational approaches that college students like were literary video, practical activities and network media. Conclusion College students have a general understanding of traditional Chinese medicine culture, but they have deep emotions about it, and have a correct attitude towards western medicine culture, and they are willing to inherit traditional Chinese medicine culture. However, the current situation of relevant education and teaching strategies is not very satisfactory. They hope to increase college students' confidence in traditional Chinese medicine culture by carrying out video network teaching and organizing practical activities. Reference | Related Articles | Metrics | Comments（0）

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Current situation and development strategy of community hospice care in China JIN Yan, QIAO Yanhua Journal of Hebei Medical College for Continuing Education    2022, 39 (1): 54-60.   DOI: 10.3969/j.issn.1674-490X.2022.01.008 Abstract （652）      PDF（pc） （489KB）（474）       Knowledge map    Save By combing the development model and experience of community hospice care in China, this paper analyzes the main problems existing in the development of community hospice care, and puts forward reasonable suggestions for the development of community hospice care in China, such as increasing support and guarantee, strengthening the construction of talent team, establishing a correct concept of life and death so as to promote the faster and better development of domestic community hospice care services. Reference | Related Articles | Metrics | Comments（0）

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Medical Reserch and Education    2018, 35 (6): 52-64.   DOI: 10.3969/j.issn.1674-490X.2018.06.011 Abstract （651）      PDF（pc） （657KB）（422）       Knowledge map    Save The idea of medicine and food homology is be long-existing in China and the idea will be accepted by the world with the attention paid by the state to the development of the Chinese medicine industry into the world. In this paper, we reviewed the origin, application status and development prospect of edible homologous culture, and summarized the impact of various links such as quality standards, testing methods, enterprises and laws and regulations on edible homologous products. The corresponding countermeasures were put forward as to the problems, that is, develop a sound quality standards, using a variety of testing methods, emphasis on scientific research innovation, and strengthen supervision and management to promote the development of Chinese medicine and food homologous industry. Reference | Related Articles | Metrics | Comments（0）

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Advances on determination methods of flavonoids in Chinese herbal medicine YANG Hui,YANG Tianrun,MA Ziyun Journal of Hebei Medical College for Continuing Education    2022, 39 (3): 9-13.   DOI: 10.3969/j.issn.1674-490X.2022.03.002 Abstract （648）      PDF（pc） （436KB）（450）       Knowledge map    Save Flavonoids are a kind of natural organic compounds widely existing in plants and are abundant in many Chinese herbal medicines. As an effective component of many traditional Chinese medicines, flavonoids play an important role in the treatment of diseases due to their extensive physiological or pharmacological activities, and are widely used in clinical practice. Therefore, the determination of such compounds in Chinese herbal medicine is one of the important links in drug quality control. In this paper, different determination methods of flavonoids in Chinese herbal medicine are reviewed. Reference | Related Articles | Metrics | Comments（0）

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Journal of Hebei Medical College for Continuing Education    2020, 37 (6): 48-53.   DOI: 10.3969/j.issn.1674-490X.2020.06.008 Abstract （643）      PDF（pc） （436KB）（515）       Knowledge map    Save With the more and more clinical application of Traditional Chinese Medicine, Daqinglong decoction as a prescription has been fully studied in modern clinical application as a classical prescription and used as a common prescription of Traditional Chinese Medicine in clinical treatment of various diseases. This paper mainly focuses on the application of Daqinglong decoction in the treatment of acute bronchitis in children, pediatric asthma, influenza and exogenous fever, primary skin amyloidosis, and other diseases with external cold and internal heat syndrome, so as to provide a reference for the clinical application of Daqinglong decoction. Reference | Related Articles | Metrics | Comments（0）

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Medical Reserch and Education    2018, 35 (6): 42-47.   DOI: 10.3969/j.issn.1674-490X.2018.06.009 Abstract （640）      PDF（pc） （429KB）（237）       Knowledge map    Save Objective To compare the efficacy and safety of amisulpride and risperidone in the treatment of schizophrenia with negative symptoms.Methods Patients with schizophrenia who were hospitalized in Mental Health Center of Hebei Province were included in the study. Patients who met the inclusion criteria and did not meet the exclusion criteria were randomly assigned to the amisulpride group and the risperidone group(35 cases in each group ). Positive and negative symptom scales(PANSS), negative symptom scales(SANS), clinical overall impression scale(CGI-S), and side effects scale(TESS)were evaluated at the time of enrollment, 4 weeks, and 8 weeks. Results Thirty-two patients in the amisulpride group were examined and 31 patients in the risperidone group were determined. The dose of amisulpride group was(665.63±167.74)mg and the dose of risperidone group was(4.32±0.98)mg. PANSS negative symptom scores and SANS scores in the amisulpride group were lower than those in the risperidone group at 4 and 8 weekends(P<0.05). PANSS, SANS, and CGI-S scores were compared at 8 weeks. The scores were decreased when enrolled, and the difference was statistically significant(P<0.05). There were no serious adverse reactions in the two groups. The adverse reactions were different(56.25% vs. 67.74%, χ2=0.882, P=0.348). The amisulpride group mainly relied on adverse reactions such as secretory, weight gain, tremor, and dry mouth. Risperidone was mainly caused by adverse reactions such as tremor, sedation, constipation, and tachycardia. Conclusion Both amisulpride and risperidone can improve the efficacy of negative symptoms as schizophrenia, but amisulpride is more effective in improving negative symptoms. Reference | Related Articles | Metrics | Comments（0）

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Medical Reserch and Education    2019, 36 (4): 24-29.   DOI: 10.3969/j.issn.1674-490X.2019.04.005 Abstract （638）      PDF（pc） （412KB）（394）       Knowledge map    Save Although the therapeutic effect of adult Ph chromosome negative acute lymphocyte(Ph-ALL)is lagging behind that of childhood acute lymphoblastic leukemia, the gap is gradually narrowing with the progress of understanding the biological characteristics of ALL, which is transforming the progress of therapeutic effect. In adolescents and young adults with acute lymphoblastic leukemia adapted from pediatric protocols,risk stratification based on genetic characteristics and minimal residual disease, and adjustment of post-remission treatment further improve the therapeutic effect of patients. In recent years, immunotherapy based on monoclonal antibodies has achieved initial success in the treatment of adult Ph-ALL. In this paper, the recent developments on the treatment of Ph-ALL is briefly summarized. Reference | Related Articles | Metrics | Comments（0）

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Medical Reserch and Education    2019, 36 (4): 41-46.   DOI: 10.3969/j.issn.1674-490X.2019.04.008 Abstract （630）      PDF（pc） （389KB）（517）       Knowledge map    Save Objective To understand the current situation of college students' anxiety and depression in colleges and universities, analyze the related factors of college students' anxiety and depression, and provide evidence for the development of college students' psychological problems prevention and treatment. Methods The questionnaires were designed with the self-rating anxiety scale and the depression self-assessment scale. Stratified cluster sampling method was used to randomly select students of university to carry out surveys. Results The prevalence of anxiety was 22.73% in college students of the university, and the average score of anxiety self-rating anxiety scale was 43.18±8.66 points, the prevalence of depression was 29.32%, and the average score of depression self-rating scale was 47.14±10.59 points. Anxiety was influenced by gender, family type, left behind experience, and whether always stays up late, depression was influenced by the type of professional, the type of family, and whether always stays up late. Conclusion The prevalence of anxiety and depression among college students is higher, and the intervention should be accurately targeted. Reference | Related Articles | Metrics | Comments（0）

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Medical Reserch and Education    2018, 35 (1): 1-6.   DOI: 10.3969/j.issn.1674-490X.2018.01.001 Abstract （624）      PDF（pc） （1116KB）（445）       Knowledge map    Save Hospice care is a special way of caring provided by an interdisciplinary care team for patients with incurable illness and their family members. The care team offers holistic care to meet physical, psychological, social and spiritual needs of patients and assists family during bereavement. Internationally, referral to hospice requires a certification of terminal illness that specifies a prognosis of 6-month or less. The medical director helps the patient to choose the model of care that meets their needs and goals of treatment and care. Definition of hospice care, eligible patients and family members, referral to hospice, the interdisciplinary care team and the care offered in hospice, and models of hospice care as well as the differences between hospice and palliative care are described in this paper with a purpose to help healthcare providers to gain a better understanding of hospice care from an international perspective. Reference | Related Articles | Metrics | Comments（0）

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Discussion on building the harmony doctor-patient relationship from the angle of ethics GUO Ningyue Medical Reserch and Education    2015, 32 (5): 102-108.   DOI: 10.3969/j.issn.1674-490X.2015.05.025 Abstract （620）      PDF（pc） （541KB）（812）       Knowledge map    Save To explore the doctor-patient relationship from the perspective of ethics , we found that it is a special and multi-level relationships, and also a social relationship as well as a moral relationship. Therefore, under the system of the market economy, it is necessary to introduce the ethical dimension in order to build a harmonious doctor-patient relationship. This paper will do an ethical research on the crux of the deterioration of the doctor-patient relationship in China and put forward the ethical countermeasures of building a harmonious doctor- patient relationship. Reference | Related Articles | Metrics | Comments（0）

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Medical Reserch and Education    2011, 28 (3): 49-54.   DOI: 10.3969/j.issn.1674-490X.2011.03.014 Abstract （611）      PDF（pc） （372KB）（720）       Knowledge map    Save Reference | Related Articles | Metrics | Comments（0）

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Effects of intravenous immunoglobulin in children with severe hand-foot-mouth disease MA Shiheng, LI Ming Medical Reserch and Education    2015, 32 (5): 1-3.   DOI: 10.3969/j.issn.1674-490X.2015.05.001 Abstract （610）      PDF（pc） （485KB）（392）       Knowledge map    Save Objective To study the effects of intravenous immunoglobulin in children with severe hand-foot-mouth disease (HFMD). Methods The medical records of 59 children with severe hand-foot-mouth disease were reviewed. Children with intravenous immunoglobul in therapy were selected as treatment group,the others as control group. Effects of two groups were compared. Results Pyretolysis time, the skin rash regression time, the nervous system symptoms disappeard time, and hospital stays in treatment group were (4.52±1.41)d, (6.35±1.93)d, (4.06±1.25)d, (9.94±2.14)d, respectively, in control group were (5.78±1.12)d, (8.03±2.74)d, (5.53±1.50)d, (11.31±2.05)d, respectively. They were shorter in treatment group than that in control group (P<0.05). Conclusion Intravenous immunoglobulin was safe and effective in children with severe hand-foot-mouth disease. Reference | Related Articles | Metrics | Comments（0）

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Journal of Hebei Medical College for Continuing Education    2021, 38 (2): 32-35.   DOI: 10.3969/j.issn.1674-490X.2021.02.006 Abstract （602）      PDF（pc） （401KB）（123）       Knowledge map    Save Objective To analyze the coincidence of platelet aggregation alarm information of Sysmex XN-1000 blood cell analyzer(hereafter referred to as XN-1000)and explore its treatment method.Methods A total of 123 inpatients with platelet aggregation alarm value >100 in whole blood cell analysis were collected, which were the high value group.123 cases with similar platelet values of age and gender and alarm value of platelet aggregation 0-100 were randomly selected as the low value group.Blood smear was used to determine platelet aggregation and manual platelet count.Results In the high value group, there were 53 positive and 70 negative cases of platelet aggregation, while in the low value group, there were 1 positive and 122 negative cases.The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of platelet aggregation alarm were 98.15%, 63.54%, 43.09%, 99.19% and 71.14%, respectively.Conclusion XN-1000 platelet aggregation alarm information can well screen out platelet aggregation and is not easy to miss diagnosis, but it's accuracy needs to be further verified by manual microscopic examination. Reference | Related Articles | Metrics | Comments（0）