Advance on intestinal mucosal barrier in patients with acute cerebral insult

doi:10.3969/j.issn.1674-490X.2013.04.018

Abstract

Abstract: In recent years ,some studies show that acute cerebral insult can damage gut barrier function, resulting in bacterial translocation and endotoxemia, causing multiple organ dysfunction and systemic inflammatory response syndrome, serious impact on the prognosis of patients, this paper describes the different detection index of intestinal barrier function, intending to make the neurology the physician to pay attention to the protect the intestinal function.

Key words: acute cerebral insult, intestinal mucosal barrier, Bacterial translocation, endotoxemia, multiple organ dysfunction syndrome, systemic inlfammatory response syndrome

CLC Number:

R651

WANG Huiling,LI Tongkai,LI Qiang,CHEN Yumin. Advance on intestinal mucosal barrier in patients with acute cerebral insult[J]. Medical Reserch and Education, 2013, 30(4): 72-74,88.

References

[1] 段秀梅. 脑源性MOF38例临床分析 [J]. 中国社区医师（医学专业） 2012.doi:10.3969/j.issn.1007-614x.2012.22.043
[2] 陈意生. 多器官功能障碍综合征的病理基础 [J]. 创伤外科杂志 2001.doi:10.3969/j.issn.1009-4237.2001.01.043
[3] 李维勤, 刘海燕, 黎介寿, LI Wei-qin, LIU Hai-yan, LI Jie-shou. 肠道屏障功能的检测及其诊断价值 [J]. 诊断学理论与实践 2009.
[4] 王燕斌, 杨昭徐, WANG Yan-bin, YANG Zhao-xu. 肠黏膜血流改变在创伤性脑损伤大鼠肠黏膜屏障应激性变化中的作用 [J]. 中国临床营养杂志 2008.doi:10.3881/j.issn.1008-5882.2008.05.004
[5] 陈秀凯, 蒲践一, 邱方, 程爱国, 刘刚. 二胺氧化酶与D-乳酸对脑损伤大鼠肠屏障功能的监测意义 [J]. 中国煤炭工业医学杂志 2003.doi:10.3969/j.issn.1007-9564.2003.07.079
[6] 郎宇璜, 李文纲, 周超, LANG Yu-huang, LI Wen-gang, ZHOU Chao. 不同程度创伤性脑损伤后肠黏膜屏障功能的变化 [J]. 创伤外科杂志 2011.doi:10.3969/j.issn.1009-4237.2011.06.019
[7] 齐志伟, 于学忠, 刘业成, 梁璐, 徐军, 朱华栋, 王仲, 马遂. 紧密连接ZO-1蛋白在缺血性脑卒中肠黏膜改变的意义 [J]. 北京医学 2011.
[8] 李娟, 姜辉, 魏金霞. 肠功能障碍诊断的新进展 [J]. 中国中西医结合消化杂志 2012.doi:10.3969/j.issn.1671-038X.2012.07.015
[9] 徐欣萍, 安傅, 邹军, 啜佳然, 朱玉群, 徐有青, XU Xin-ping, AN Bo, Zou jun, CHUAI Jia-ran, ZHU Yu-qun, XU You-qing. 缺血性脑卒中大鼠肝损害及与肠源性内毒素血症的关系研究 [J]. 湖南中医药大学学报 2012.doi:10.3969/j.issn.1674-070X.2012.06.003.007.04
[10] 徐爱蕾, 王为. 降钙素原检测方法学和临床意义的研究进展 [J]. 临床军医杂志 2012.doi:10.3969/j.issn.1671-3826.2012.01.098
[11] 毕鹏翔, 唐建平, 周小莉, 范学文. 动态监测ICU卒中患者血清降钙素原水平的临床意义 [J]. 齐齐哈尔医学院学报 2011.doi:10.3969/j.issn.1002-1256.2011.13.009
[12] Liboni KC, Li N, Scumpia PO, Neu J. Glutamine modulates LPS-induced IL-8 production through IkappaB/NF-kappaB in human fetal and adult intestinal epithelium. [J]. The Journal of Nutrition 2005, 2(2).
[13] It's all in the gut: Introducing the concept of acute bowel injury and acute intestinal distress syndrome... [J]. Critical care medicine 2009, 1(1).
[14] Catalioto RM, Maggi CA, Giuliani S. Intestinal epithelial barrier dysfunction in disease and possible therapeutical interventions. [J]. Current medicinal chemistry 2011, 3(3).
[15] 宿英英. 神经系统急危重症监护与治疗 [M]. 北京:人民卫生出版社 2005.
[16] Tsunooka N, Maeyama K, Hamada Y, Imagawa H, Takano S, Watanabe Y, Kawachi K. Bacterial translocation secondary to small intestinal mucosal ischemia during cardiopulmonary bypass. Measurement by diamine oxidase and peptidoglycan. [J]. European journal of cardio-thoracic surgery: Official journal of the European Association for Cardio-thoracic Surgery 2004, 2(2).
[17] UZZAN B, COHEN R, NICOLAS P. Procalcitonin as a diagnostic test for sepsis in critically ill adults and after surgery or trauma:a systematic review and meta analysis [J]. CRITICAL CARE MEDICINE 2006, 34(07).