doi:10.3969/j.issn.1674-490X.2018.03.001

Abstract

Abstract: Fractalkine(FKN)is called CX3CL1.It is the sole member of the CX3C family and exists in both membrane-bound and soluble forms. FKN is expressed on human endothelial cells and most organs, such as heart, liver and brain. In recent years it has been discovered that FKN is involved not only in chemotaxis, adhesion and inflammation but also in the proliferation and apoptosis of certain cells. This article mainly reviews FKN as an anti-apoptotic factor, through its sole receptor CX3CR1, plays an anti-apoptotic role in various disease models. Their mediated survival signals are involved in the regulation of normal physiological and pathological processes and are closely related to the occurrence and development of the disease. FKN/CX3CR1 is expected to become a new target for disease prevention and treatment.

Key words: fractalkine, CX3CR1, anti-apoptotic

CLC Number:

References

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