doi:10.3969/j.issn.1674-490X.2023.03.003

Abstract

Abstract: Gastric cancer is a common malignant tumor of the digestive system, with high morbidity and high mortality. There is still no effective method for its screening and early diagnosis. Long non-coding RNA(lncRNA)is a kind of non-coding RNAs with a length of more than 200 nucleotides, which is abnormally expressed in a variety of malignant tumors. Exosomes are membranous vesicles with a diameter of about 40-100 nm, which are widely distributed in various body fluids. They play an important role in intercellular communication, containing various biologically active substances such as nucleic acid, protein. More and more studies have shown that exosomal lncRNA plays an important regulatory role in the proliferation, invasion, metastasis and treatment resistance of gastric cancer cells. Regulating its expression level can promote or inhibit the progress of gastric cancer. In addition, some exosomal lncRNA have promising potential as diagnostic and prognostic markers for gastric cancer, and even as therapeutic targets for gastric cancer. Combined with the relevant research reports at home and abroad in recent years, this paper reviews the research developments of exosomal lncRNA in gastric cancer.

Key words: gastric cancer, exosomes, long non-coding RNA, diagnosis, prognosis

CLC Number:

References

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