脑缺血后适应的基础研究及其临床应用前景

doi:10.3969/j.issn.1674-490X.2014.04.018

摘要/Abstract

摘要： 缺血后适应的提出源于缺血预适应，脑缺血后适应是指在脑缺血后给予一次或多次反复短暂的动脉闭塞后再灌注以期达到减轻脑组织缺血再灌注损伤的目的。相对于预适应，后适应具有临床治疗的可行性。近年来诸多研究发现其具有明显的脑保护作用，主要对其发现、发展、脑保护作用机制及其临床应用前景进行综述。

关键词: 缺血后适应, 脑缺血, 脑保护, 缺血预适应

Abstract: Ischemic postconditioning is a concept originally defined to contrast with that of ischemic preconditioning. While both preconditioning and postconditioning confer a neuroprotective effect on brain ischemia, preconditioning is a sublethal insult performed in advance of brain ischemia, and postconditioning, which conventionally refers to a series of brief occlusions and reperfusions of the blood vessels, is conducted after ischemia/reperfusion. In recent years, extensive studies show that postconditioning has apparently protective effects. We mainly review the discovery and development, the underlying mechanisms and clinical application of it.

Key words: ischemic postconditioning, cerebral ischemia, neuroprotection, ischemic preconditioning

中图分类号:

李盼,苏立凯,李晓芳. 脑缺血后适应的基础研究及其临床应用前景[J]. 医学研究与教育, 2014, 31(4): 75-80.

LI Pan,SU Likai,LI Xiaofang. The experimental research and clinical application prospect of ischemic postconditioning in brain ischemia[J]. Medical Reserch and Education, 2014, 31(4): 75-80.

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