性激素结合球蛋白的表达与膀胱尿路上皮癌发病率的相关性

doi:10.3969/j.issn.1674-490X.2011.03.006

医学研究与教育 ›› 2011, Vol. 28 ›› Issue (3): 22-26.DOI: 10.3969/j.issn.1674-490X.2011.03.006

性激素结合球蛋白的表达与膀胱尿路上皮癌发病率的相关性

李昱¹,梁栋丽²,杨文增¹,马涛¹,魏若晶¹

1.河北大学附属医院泌尿外科,河北保定,071000
2.河北大学医院,河北保定,071000

收稿日期:2016-10-09 修回日期:2016-10-09 出版日期:2011-06-25 发布日期:2011-06-25

Expression and significance of sex hormone-binding globulin in urothelial carcinoma of the bladder

LI Yu¹,LIANG Dongli²,YANG Wenzeng¹,MA Tao¹,WEI Ruojing¹

Received:2016-10-09 Revised:2016-10-09 Online:2011-06-25 Published:2011-06-25

摘要/Abstract

摘要： 目的探讨性激素结合球蛋白(SHBG)在膀胱尿路上皮癌(UC)中的表达及意义.方法采用免疫组织化学EnVision法检测SHBG在121例膀胱UC中的表达,分析SHBG表达与临床病理特征间的关系.结果121例UC中,SHBG阳性57例(47.11％).低级别UC 87例,其中50例SHBG阳性(57.47％)；高级别UC 34例,其中7例SHBG阳性(20.59％),差异有统计学意义(x2=13.347,P=0.000),20例伴有淋巴结转移患者中5例SHBG阳性(25.00％),其阳性率显著低于不伴有淋巴结转移者(x2=4.700,P=0.030),其他临床病理特征比较差异无统计学意义.结论SHBG在膀胱UC中阳性率较高,可能是重要的肿瘤增殖负调控因子.

关键词: 膀胱肿瘤, 尿路上皮癌, 性激素结合球蛋白

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R737

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李昱,梁栋丽,杨文增,马涛,魏若晶. 性激素结合球蛋白的表达与膀胱尿路上皮癌发病率的相关性[J]. 医学研究与教育, 2011, 28(3): 22-26.

LI Yu,LIANG Dongli,YANG Wenzeng,MA Tao,WEI Ruojing. Expression and significance of sex hormone-binding globulin in urothelial carcinoma of the bladder[J]. Medical Reserch and Education, 2011, 28(3): 22-26.

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性激素结合球蛋白的表达与膀胱尿路上皮癌发病率的相关性

Expression and significance of sex hormone-binding globulin in urothelial carcinoma of the bladder

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[1]	何廉波,杨磊. 长链非编码RNA-scarna 4在膀胱尿路上皮癌的作用研究[J]. 医学研究与教育, 2018, 35(2): 26-31.
[2]	魏若晶,贾宁,杨文增,周洪月,赵春利,张彦桥. 膀胱癌组织中MDR1基因产物P-GP170、GST-π和TOPOⅡ的表达及意义[J]. 医学研究与教育, 2010, 27(1): 7-10.