卒中后抑郁伴高同型半胱氨酸血症研究

医学研究与教育 ›› 2014, Vol. 31 ›› Issue (5): 68-72.

卒中后抑郁伴高同型半胱氨酸血症研究

高天初¹，李会敏²，刘喜艳¹，史福平²

1. 河北大学医学部，河北保定 071000；2. 河北大学附属医院神经内科，河北保定 071000

出版日期:2014-10-25 发布日期:2014-10-25
通讯作者: 李会敏（1963—），女，河北保定人，主任医师，硕士，硕士生导师，主要从事脑血管病的预防和治疗研究。E-mail: 13682810670@qq.com
作者简介:高天初（1987—），男，河北保定人，医师，在读硕士，主要从事脑血管病的预防和治疗研究。E-mail: 316336070@qq.com

Research on post-stroke depression with hyperhomocysteinemia

GAO Tianchu¹, LI Huimin², LIU Xiyan¹, SHI Fuping²

1. Health Science Center, Hebei University, Baoding 071000, China; 2. Department of Neurology, Affiliated Hospital of Hebei University, Baoding 071000, China

Online:2014-10-25 Published:2014-10-25

摘要/Abstract

摘要： 脑卒中患者的 1/3 发展为卒中后抑郁（post-stroke depression，PSD）。PSD 加剧了脑卒中所带来的负面影响，增加了病死率，减缓了神经功能的恢复时间，削弱了恢复程度。目前研究表明高同型半胱氨酸血症（hyperhomocysteinemia，HHcy）与普通人群中的脑卒中的发生具有相关性，但其与 PSD 的发生尚未明确。近年来，有关二者之间各方面的相关性研究较多（如流行病学、病理生理学机制、临床表现、诊断评估及药物治疗等），引起了广泛关注。

关键词: 卒中后抑郁, 高同型半胱氨酸血症, 临床研究

Abstract: One third of all stroke survivors develop post-stroke depression(PSD). It’s negatively impacts stroke outcome with increased morbidity, mortality and poorer functional recovery. Accumulating data suggest that hyperhomocysteinemia(HHcy) be associated with the risk of stroke in the general population, but the relationship remains unclear in PSD patients. In recent years, there have been a lot of studies on the correlation between them in many aspects (such as epidemiology, pathophysiology, clinical manifestation, diagnosis, and biological treatment), which has aroused wide concern.

Key words: post-stroke depression(PSD), hyperhomocysteinemia(HHcy), clinical research

中图分类号:

R749

高天初，李会敏，刘喜艳，史福平. 卒中后抑郁伴高同型半胱氨酸血症研究[J]. 医学研究与教育, 2014, 31(5): 68-72.

GAO Tianchu, LI Huimin, LIU Xiyan, SHI Fuping. Research on post-stroke depression with hyperhomocysteinemia[J]. Medical Reserch and Education, 2014, 31(5): 68-72.

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