氢气在神经退行性疾病中的神经保护作用机制及研究进展

doi:10.3969/j.issn.1674-490X.2026.04.001

摘要/Abstract

摘要： 神经退行性疾病是多种原因引起的、以神经元进行性损伤为特征的疾病,包括阿尔茨海默病、帕金森病、肌萎缩侧索硬化症等。其发病机制涉及氧化应激、神经炎症、线粒体功能障碍及蛋白异常聚集等多种过程,当前缺乏有效的治疗手段。氢气通过减轻氧化应激、抑制神经炎症及调控细胞凋亡等多途径发挥神经保护作用,综述氢气在神经保护中的作用机制及临床研究进展,以期为未来的临床应用提供新的思路。

关键词: 氢气, 神经退行性疾病, 帕金森病, 阿尔茨海默病

Abstract: Neurodegenerative diseases are a class of disorders caused by multiple factors, characterized by progressive neuronal damage, with Alzheimer disease(AD)and Parkinson disease(PD)and amyotrophic lateral sclerosis(ALS)as typical representatives. Their pathogenesis is closely associated with various pathological processes, including oxidative stress, neuroinflammation, mitochondrial dysfunction, and abnormal protein aggregation, and effective therapeutic methods are currently lacking. In recent years, studies have shown that hydrogen exerts neuroprotective effects through multiple pathways, such as alleviating oxidative stress, inhibiting neuroinflammation, and regulating cell apoptosis. This review summarizes the mechanisms of hydrogen in neuroprotection and the progress of related clinical studies, aiming to provide new ideas for its future clinical application in the treatment of neurodegenerative diseases.

Key words: hydrogen, neurodegenerative diseases, Parkinson disease, Alzheimer disease

中图分类号:

R741

马博,王红杰. 氢气在神经退行性疾病中的神经保护作用机制及研究进展[J]. 医学研究与教育, 2026, 43(4): 1-13.

Ma Bo,Wang Hongjie. Mechanisms and research progress of hydrogen in neurodegenerative diseases[J]. Journal of Hebei Medical College for Continuing Education, 2026, 43(4): 1-13.

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