鸡血藤总黄酮对大鼠佐剂性关节炎作用的实验研究

医学研究与教育 ›› 2014, Vol. 31 ›› Issue (5): 1-4.

• 基础研究 • 下一篇

鸡血藤总黄酮对大鼠佐剂性关节炎作用的实验研究

刘仰斌，张志花

赣南医学院，江西赣州 341000

收稿日期:2015-01-16 修回日期:2015-01-16 出版日期:2014-10-25 发布日期:2014-10-25
作者简介:刘仰斌（1970—），男，江西赣州人，副教授，硕士，主要从事免疫细胞与神经疼痛机制研究。E-mail: 15979776628@163.com

Experimental study of net cliffbean total flavonoids on adjuvant arthritis in rats

LIU Yangbin, ZHANG Zhihua

Gannan Medical University, Ganzhou 341000, China

Received:2015-01-16 Revised:2015-01-16 Online:2014-10-25 Published:2014-10-25

摘要/Abstract

摘要： 目的探讨鸡血藤总黄酮对大鼠佐剂性关节炎的治疗作用，并探讨其作用机制。方法采用弗氏完全佐剂诱导大鼠佐剂性关节炎动物模型；观察不同浓度鸡血藤总黄酮对佐剂性关节炎大鼠的慢性足肿胀度、血清中一氧化氮（NO）含量及谷胱甘肽过氧化物酶（GSH-Px）活性的影响。结果与佐剂性关节炎模型组相比，高、低剂量的鸡血藤总黄酮均能抑制大鼠慢性足肿胀，降低关节炎大鼠血清 NO 水平，并使 GSH-Px 含量增加。结论鸡血藤总黄酮对大鼠佐剂性关节炎有治疗作用，其作用可能与其恢复抗氧化物酶活性、清除自由基的作用有关。

关键词: 鸡血藤, 总黄酮, 佐剂性关节炎, 抗氧化作用

Abstract: Objective To study the effects of net cliffbean total flavonoids on adjuvant arthritis and its mechanism in rats. Methods Rats model with rheumatoid arthritis were injected freund complete adjuvant, to observe the effects of the high and low dosage of net cliffbean total flavonoids to the chronic paw swelling, nitric oxide(NO) content and glutathione peroxidase (GSH-Px) activity in serum. Results Both net cliffbean total flavonoids groups could reduce the swelling of the model rats, change the level of serum NO, which were lower than that of the model group, whereas the net cliffbean total flavonoids groups could increase the activity of serum GSH-Px. Conclusion Net cliffbean total flavonoids had therapeutic action to rheumatoid arthritis rats, and the mechanism probably was that net cliffbean total flavonoids could strengthen the activity of antioxidase, and scavenge oxygen-free radicals.

Key words: net cliffbean, total flavonoids, adjuvant arthritis, antioxidation

中图分类号:

刘仰斌，张志花. 鸡血藤总黄酮对大鼠佐剂性关节炎作用的实验研究[J]. 医学研究与教育, 2014, 31(5): 1-4.

LIU Yangbin, ZHANG Zhihua. Experimental study of net cliffbean total flavonoids on adjuvant arthritis in rats[J]. Medical Reserch and Education, 2014, 31(5): 1-4.

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鸡血藤总黄酮对大鼠佐剂性关节炎作用的实验研究

Experimental study of net cliffbean total flavonoids on adjuvant arthritis in rats

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