联合放化疗对鼻咽癌患者淋巴细胞亚群影响的观察

doi:10.3969/j.issn.1674-490X.2015.05.011

医学研究与教育 ›› 2015, Vol. 32 ›› Issue (5): 42-45.DOI: 10.3969/j.issn.1674-490X.2015.05.011

联合放化疗对鼻咽癌患者淋巴细胞亚群影响的观察

刘斌¹，刘丽霞²，臧爱民¹，马涛³，王萍⁴，张永刚⁵

1. 河北大学附属医院肿瘤内科，河北保定 071000；2. 河北大学附属医院功能科，河北保定 071000；3. 保定市第一中心医院肿瘤外科，河北保定 071000；4. 保定市第一中心医院质管科教科，河北保定 071000 5. 河北大学附属医院（北院）头颈外科，河北保定 071000

出版日期:2015-10-25 发布日期:2015-10-25
作者简介:刘斌（1981—），男，河北保定人，主治医师，硕士，主要从事恶性肿瘤放化疗及分子靶向治疗E-mial: 401929599@qq.com
基金资助:
保定市科学技术研究与发展计划项目（112F015）

Observation of influence of radiotherapy and chemotherapy on T Lymphocytes subsets in patients with nasopharyngeal carcinoma

LIU Bin¹, LIU Lixia², ZANG Aimin¹, MA Tao³, WANG Ping⁴, ZHANG Yonggang⁵

1. Department of Oncology, Affiliated Hospital of Hebei University, Hebei Baoding 071000; 2. Functions Branch, Affiliated Hospital of Hebei University, Hebei Baoding 071000; 3. surgical Department Baoding NO.1 central Hospital, Hebei Baoding 071000; 4. Department of Education Baoding NO.1 central Hospital, Hebei Baoding 071000; 5. surgical Department, Affiliated Hospital of Hebei University(North), Hebei Baoding 071000

Online:2015-10-25 Published:2015-10-25

摘要/Abstract

摘要： 目的观察鼻咽癌患者同步放化疗前、后的细胞免疫功能变化，以探讨联合放化疗对鼻咽癌患者免疫功能的影响。方法应用 FACS Calibur 流式细胞仪对 60 例鼻咽癌患者和 60 名健康体检者同步放化疗前、后外周血 T、B 淋巴细胞亚群进行检测，并分别对健康体检者与鼻咽癌患者同步放化疗前、鼻咽癌患者同步放化疗前与放化疗后的检测值进行比较。结果鼻咽癌患者放疗前与健康体检者对比，CD3+、CD16+56+和CD19+均值差异无统计学意义，t 值分别为1.567、0.971 和 1.561，P 值分别为 0.078、0.392 和 0.240；CD4+、CD4+/CD8+ 均值下降差异有统计学意义，t 值分别为 2.389 和2.358，P 值分别为 0.013 和 0.027；CD8+均值升高差异有统计学意义，t=-2.342，P=0.019。鼻咽癌患者同步放化疗后与放化疗前对比，CD3+、CD4+、CD4+/CD8+ 均值明显下降，差异有统计学意义，t值分别为 -7.163、-11.217 和 3.817，P 值均 <0.01；CD8+ 与 CD16+56+ 均值明显上升，差异有统计学意义，t 值分别为 -8.271 和 4.383，P 值分别为 0.01 和 0.001；CD19+ 均值差异无统计学意义，t=-0.986，P=0.323。结论鼻咽癌患者免疫功能下降，外周血 T、B 淋巴细胞亚群的检测对判断患者的免疫功能有参考作用。

关键词: 鼻咽癌, 放射疗法, 药物疗法, T 细胞亚群, 流式细胞术

Abstract: Objective To explore the relationships between changes of immune functions in patients with nasopharyngeal carcinoma(NPC)pre-chemoradiotherapy and post chemoradiotherapy. Methods The flow cytometry(FACS Calibur) was used to detect the blood T, B Lymphocytes subsets of 60 healthy check-ups and 60 NPC patients before and after chemoradiotherapy. The immune indexes of changes before and after the radiotherapy were analyzed and their test values were compared. Results There were no significant differencesin CD3+, CD16+56+, CD19+(t were 1.567; 0.971; 1.561, P were 0.078; 0.392; 0.240)between the healthy check-ups and the NPC patients before chemoradiotherapy. CD4+, CD4+/CD8+ had a downward trend(t were2.389; 2.358, P were 0.01, 0.01)while CD8+ had an upward trend (t=-2.342, P=0.019), which was statistically significant. CD3+, CD4+, CD4+/CD8+ were significantly different before and after the chemoradiotherapy,CD3+, CD4+, CD4+/CD8+ gradually down, which had significant differences(t were -7.163, -11.217, 3.817 P<0.01); CD8+, CD16+56+ gradually up,which had significant differences(t were -8.271, 4.383, P were 0.010.001).There was no significant difference in CD19+ (t=-0.986, P=0.323). Conclusions The immune functions get lower in the NPC patients after chemoradiotherapy and can be estimated by the test of the blood T, B Lymphocytes subsets.

Key words: nasopharyngeal, radiotherapy, surgery, T lymphocytesubsets, flow cytome-try

中图分类号:

R445

刘斌，刘丽霞，臧爱民，马涛，王萍，张永刚. 联合放化疗对鼻咽癌患者淋巴细胞亚群影响的观察[J]. 医学研究与教育, 2015, 32(5): 42-45.

LIU Bin, LIU Lixia, ZANG Aimin, MA Tao, WANG Ping, ZHANG Yonggang. Observation of influence of radiotherapy and chemotherapy on T Lymphocytes subsets in patients with nasopharyngeal carcinoma[J]. Medical Reserch and Education, 2015, 32(5): 42-45.

联合放化疗对鼻咽癌患者淋巴细胞亚群影响的观察

Observation of influence of radiotherapy and chemotherapy on T Lymphocytes subsets in patients with nasopharyngeal carcinoma

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