固有免疫应答在抗布鲁菌感染过程中的作用

doi:10.3969/j.issn.1674-490X.2015.03.018

医学研究与教育 ›› 2015, Vol. 32 ›› Issue (3): 82-86.DOI: 10.3969/j.issn.1674-490X.2015.03.018

固有免疫应答在抗布鲁菌感染过程中的作用

高微，王梦，曹志然

河北大学基础医学院，河北保定 071000

出版日期:2015-06-25 发布日期:2015-06-25
通讯作者: 曹志然（1963—），女，河北景县人，教授，硕士生导师，主要从事抗感染免疫研究。E-mail: 919196928@qq.com
作者简介:高微（1990—），女，河北廊坊人。
基金资助:
河北省自然科学基金资助项目（C2010000243）；河北大学国家级大学生创新训练计划项目（201410075028）

The role of innate immune response during infection of Brucella

GAO Wei, WANG Meng, CAO Zhiran

College of Basic Medical Science of Hebei University, Baoding 071000, China

Online:2015-06-25 Published:2015-06-25

摘要/Abstract

摘要： 布鲁菌是革兰氏阴性兼性胞内寄生菌，包括牛布鲁菌、羊布鲁菌、猪布鲁菌、犬布鲁菌和海洋哺乳动物感染的布鲁菌等，其中羊布鲁菌、牛布鲁菌、猪布鲁菌和犬布鲁菌等可以通过多种途径侵入人和动物体内，其引起的布鲁菌病是一种严重的人畜共患病。固有免疫系统是机体抵抗病原体感染的第一道防线，因此在布鲁菌感染过程中发挥重要作用。现综述布鲁菌感染过程中宿主固有免疫应答发挥的作用。

关键词: 布鲁菌, 布鲁菌病, 固有免疫, 病原相关分子模式, 模式识别受体

Abstract: Brucella is a Gram-negative, facultative intracellular bacteria, which includes Brucella. abortus(cattle), B.melitensis(goats), B.suis (swine), B.canis(dogs) and Brucella infected by marine mammals,et al. B.abortus, B.melitensis, B.suis and B.canis, et al can invade into humans and animals through a variety of ways and cause Brucellosis that is a severe zoonotic desease. The innate immune system is the first line of defensing against the infection of pathogen for our organism, which plays a key role during the infection of Brucella. This paper overviews the role of innate immune response during the infection of Brucella.

Key words: Brucella, Brucellosis, innate immune, pattern-recognition receptor, pathogen-associated molecular pattern

中图分类号:

R392

高微，王梦，曹志然. 固有免疫应答在抗布鲁菌感染过程中的作用[J]. 医学研究与教育, 2015, 32(3): 82-86.

GAO Wei, WANG Meng, CAO Zhiran. The role of innate immune response during infection of Brucella[J]. Medical Reserch and Education, 2015, 32(3): 82-86.

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固有免疫应答在抗布鲁菌感染过程中的作用

The role of innate immune response during infection of Brucella

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