精子DNA损伤因素研究进展

doi:10.3969/j.issn.1674-490X.2014.03.017

摘要/Abstract

摘要： 人类精子DNA损伤是男性生育力减退的重要原因之一，其可由多种因素诱发精子DNA链断裂或使其双链变性为单链等而形成。具有DNA损伤的精子可在一定程度上逃避体内精子的优化选择机制而将遗传缺陷传递给后代，精子DNA损伤可导致胚胎发育异常、早期流产和先天畸形等相关疾病。文章通过分析评价年龄、禁欲时间、环境、精子冷冻、氧化应激、微量元素以及染色质包装异常等因素对精子DNA损伤，阐述精子DNA损伤的研究现状，为进一步阐明精子DNA损伤的发生机制以及男性不育的预防、治疗和辅助生殖技术选用高质量精子提供基础材料。

关键词: 精子DNA损伤, 年龄, 禁欲时间, 环境

Abstract: Human sperm DNA damage is one of the common causes of reducing male reproductive capacity. A number of factors can bring out the DNA strand breaks or make double-stranded DNA into single-stranded DNA. To a certain extent, some sperm with damaged DNA may escape from the sperm surveillance mechanism and transmit the damage to the offspring, which may give rise to the associated diseases such as abnormal embryonic development, early natural abortion, congenital anomalies and so on. This review assessses the damage factors of sperm DNA, which include ages, time of celibation, environment, freezing of sperm, oxidative stresse, minor element and the abnormal assembling of chromatin, which provides some basic information for elucidating the mechanism of DNA damage, prevention and treatment of male infertility as well as optimal spermatozoa selection in assisted reproductive technique.

Key words: sperm DNA damage, age, time of celibation, environment

中图分类号:

R698

葛少钦,赵峥辉,殷会莹,梁群,王川川,丁高朋,许振国. 精子DNA损伤因素研究进展[J]. 医学研究与教育, 2014, 31(3): 61-65.

GE Shaoqin,ZHAO Zhenghui,YIN Huiying,LIANG Qun,WANG Chuanchuan,DING Gaopeng,XU Zhenguo. Advances on the damage factors of sperm DNA[J]. Medical Reserch and Education, 2014, 31(3): 61-65.

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