超脉冲CO2点阵激光联合光子嫩肤治疗面部凹陷性痤疮瘢痕的疗效与安全性

doi:10.3969/j.issn.1674-490X.2026.03.005

医学研究与教育 ›› 2026, Vol. 43 ›› Issue (3): 50-57.DOI: 10.3969/j.issn.1674-490X.2026.03.005

超脉冲CO₂点阵激光联合光子嫩肤治疗面部凹陷性痤疮瘢痕的疗效与安全性

张萌¹,张胜逆¹,赵建伟¹,田文英¹,罗丁¹,任项项²,楚瑞琦¹

1. 河北大学附属医院皮肤科, 河北保定 071000;
2. 河北大学附属医院普通外科, 河北保定 071000

收稿日期:2025-11-06 出版日期:2026-06-25 发布日期:2026-06-25
通讯作者: 楚瑞琦(1968—),男,河北保定人,主任医师,博士,硕士生导师,主要从事皮肤病研究。E-mail: pfkcrq1989@163.com
作者简介:张萌(1991—),女,河北保定人,主治医师,硕士,主要从事皮肤病研究。 E-mail: pfkzm991@163.com
基金资助:
保定市科技局计划项目(2241ZF311);河北大学附属医院院内基金项目(2022QB29)

Efficacy and safety analysis of ultrapulsed fractional CO₂ laser combined with photorejuvenation in the treatment of facial atrophic acne scars

Zhang Meng¹, Zhang Shengni¹, Zhao Jianwei¹, Tian Wenying¹, Luo Ding¹, Ren Xiangxiang², Chu Ruiqi¹

1. Department of Dermatology, Affiliated Hospital of Hebei University, Baoding 071000, China; 2. Department of General Surgery, Affiliated Hospital of Hebei University, Baoding 071000, China

Received:2025-11-06 Online:2026-06-25 Published:2026-06-25

摘要/Abstract

摘要： 目的探讨超脉冲CO₂点阵激光与光子嫩肤联合应用于面部凹陷性痤疮瘢痕的疗效及安全性。方法纳入河北大学附属医院皮肤科收治的面部凹陷性痤疮瘢痕患者共60例,随机分为CO₂激光组和联合治疗组,各30例。CO₂激光组接受超脉冲CO₂点阵激光治疗,每3个月1次,共完成5次治疗;联合治疗组在接受超脉冲CO₂点阵激光治疗1个月后联合强脉冲光治疗,共完成5次治疗。结果联合治疗组的显效率(70.00%)高于CO₂激光组(36.67%),差异有统计学意义(P=0.011),且在疼痛缓解方面更具优势(P=0.007)。亚组分析表明,联合治疗对冰锥型和滚轮型瘢痕的改善优于对照组,2组总有效率均超过90%,未见严重不良事件。结论超脉冲CO₂点阵激光联合光子嫩肤是一种安全、高效的治疗策略,尤其适用于冰锥型和滚轮型凹陷性痤疮瘢痕。

关键词: 超脉冲CO₂点阵激光, 光子嫩肤, 凹陷性痤疮瘢痕, 联合治疗, 疗效, 安全性

Abstract: Objective To evaluate the clinical efficacy and safety of ultrapulsed fractional CO₂ laser combined with photorejuvenation for the treatment of facial atrophic acne scars.Methods Sixty patients with acne scars from the Department of Dermatology, Affiliated Hospital of Hebei University were randomly assigned to a CO₂ laser group and a combination treatment group, with 30 patients in each. The CO₂ laser group received ultrapulsed fractional CO₂ laser treatment once every 3 months for a total of 5 sessions. The combination treatment group received the same ultrapulsed fractional CO₂ laser treatment, and one month after each laser session, photorejuvenation treatment was added, completing a total of 5 combined treatment cycles.Results The marked improvement rate in the combination group(70.00%)was significantly higher than that in the CO₂ laser group(36.67%)(P=0.011), and the combination therapy demonstrated superior pain relief(P=0.007). Subgroup analysis showed that the combination approach led to greater improvement of icepick and rolling scars compared with the control group. The total effective rate exceeded 90% in both groups, and no serious adverse events were observed.Conclusion Ultrapulsed fractional CO₂ laser combined with photorejuvenation is a safe and effective treatment strategy, particularly suitable for icepick and rolling types of atrophic acne scars.

Key words: ultrapulse fractional CO₂ laser, photorejuvenation, atrophic acne scars, combination therapy, efficacy, safety

中图分类号:

张萌,张胜逆,赵建伟,田文英,罗丁,任项项,楚瑞琦. 超脉冲CO₂点阵激光联合光子嫩肤治疗面部凹陷性痤疮瘢痕的疗效与安全性[J]. 医学研究与教育, 2026, 43(3): 50-57.

Zhang Meng, Zhang Shengni, Zhao Jianwei, Tian Wenying, Luo Ding, Ren Xiangxiang, Chu Ruiqi. Efficacy and safety analysis of ultrapulsed fractional CO₂ laser combined with photorejuvenation in the treatment of facial atrophic acne scars[J]. Journal of Hebei Medical College for Continuing Education, 2026, 43(3): 50-57.

参考文献

[1] 冯敏, 郄永涛,王岩军,等.果酸和胶原蛋白敷料联合五味消毒饮加减治疗颜面部痤疮的临床疗效分析[J].医学研究与教育, 2015, 32(6): 34-36, 40. DOI: 10.3969/j.issn.1674-490X.2015.06.007.
[2] Hazarika N, Archana M. The psychosocial impact of acne vulgaris[J]. Indian J Dermatol, 2016, 61(5): 515-520. DOI: 10.4103/0019-5154.190102.
[3] 夏玉虹.超脉冲CO₂点阵激光治疗痤疮凹陷性瘢痕的临床疗效观察[J].青海医药杂志, 2024,54(8): 15-17.
[4] 李平松,陈啸.光子嫩肤个体化参数方案的临床应用[J].中国美容医学,2004,13(6):666-668. DOI: 10.3969/j.issn.1008-6455.2004.06.011.
[5] Dreno B, Khammari A, Orain N, et al. ECCA grading scale: an original validated acne scar grading scale for clinical practice in dermatology[J]. Dermatology, 2007, 214(1): 46-51. DOI: 10.1159/000096912.
[6] 崔佳,姚庆君,韩维鑫,等.面部痤疮凹陷性瘢痕的治疗方法及趋势[J].中国美容整形外科杂志, 2021, 32(3): 191. DOI: 10.3969/j.issn.1673-7040.2021.03.018.
[7] Makboul M, Makboul R, Abdelhafez A H, et al. Evaluation of the effect of fractional CO₂ laser on histopathological picture and TGF-β1 expression in hypertrophic scar[J]. J Cosmet Dermatol, 2014, 13(3): 169-179. DOI: 10.1111/jocd.12099.
[8] Kroon M W, Wind B S, Meesters A A, et al. Non-ablative 1550 nm fractional laser therapy not effective for erythema dyschromicum perstans and postinflammatory hyperpigmentation: a pilot study[J]. J Dermatol Treat, 2012, 23(5): 339-344. DOI: 10.3109/09546634.2011.565016.
[9] 中国医师协会皮肤科医师分会皮肤激光与理疗亚专业委员会.强脉冲光临床应用专家共识(2017)[J].中华皮肤科杂志, 2017, 50(10): 701-705. DOI: 10.3760/cma.j.issn.0412-4030.2017.10.001.
[10] Zhang M, Liu C M, Zhang S N, et al. Advances in the treatment of acne scars[J]. Front Med, 2025, 12: 1643035. DOI: 10.3389/fmed.2025.1643035.
[11] Huang J H, Luo X, Lu J Y, et al. IPL irradiation rejuvenates skin collagen via the bidirectional regulation of MMP-1 and TGF-β1 mediated by MAPKs in fibroblasts[J]. Lasers Med Sci, 2011, 26(3): 381-387. DOI: 10.1007/s10103-010-0870-1.
[12] Alexiades-Armenakas M. Assessment of the mobile delivery of infrared light(1100-1800 nm)for the treatment of facial and neck skin laxity[J]. J Drugs Dermatol, 2009, 8(3): 221-226.
[13] Salem S A M, Abdel Hameed S M, Mostafa A E. Intense pulsed light versus cryotherapy in the treatment of hypertrophic scars: a clinical and histopathological study[J]. J Cosmet Dermatol, 2021, 20(9): 2775-2784. DOI: 10.1111/jocd.13971.
[14] Daoud A A, Gianatasio C, Rudnick A, et al. Efficacy of combined intense pulsed light(IPL)with fractional CO₂-laser ablation in the treatment of large hypertrophic scars: a prospective, randomized control trial[J]. Lasers Surg Med, 2019, 51(8): 678-685. DOI: 10.1002/lsm.23092.
[15] Majid I, Imran S. Fractional CO2 laser resurfacing as monotherapy in the treatment of atrophic facial acne scars[J]. J Cutan Aesthet Surg, 2014, 7(2): 87-92. DOI: 10.4103/0974-2077.138326.
[16] 窦鹏,蔡瑶,杨枭萍.IPL联合他克莫司及皮肤屏障修复精华乳治疗红斑毛细血管扩张型玫瑰痤疮[J].中国美容医学, 2024, 33(5): 90-93. DOI: 10.15909/j.cnki.cn61-1347/r.006272.
[17] Zhou M Y, Gomes M P, Elgersma A, et al. Multiscale investigation of collagen structure in human skin and gel matrices using polarization resolved second harmonic generation microscopy[J]. Sci Rep, 2025, 15: 20025. DOI: 10.1038/s41598-025-02536-4.

超脉冲CO₂点阵激光联合光子嫩肤治疗面部凹陷性痤疮瘢痕的疗效与安全性

Efficacy and safety analysis of ultrapulsed fractional CO₂ laser combined with photorejuvenation in the treatment of facial atrophic acne scars

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价

[1]	多万发,李华. 踝关节内翻型骨关节炎患者踝上截骨术后影像学参数变化与临床疗效的相关性分析[J]. 医学研究与教育, 2025, 42(6): 26-33.
[2]	赵元奎. 丙泊酚联合依托咪酯在老年无痛胃肠镜检查中的效果观察和安全性分析[J]. 医学研究与教育, 2021, 38(1): 17-22.
[3]	赵峰,张红茹,丁乾,徐洋涛,刘倩. 启阳胶囊联合小剂量5-磷酸二酯酶抑制剂治疗2型糖尿病性勃起功能障碍[J]. 医学研究与教育, 2020, 37(3): 28-31.
[4]	霍丽娇,王琨,柏金秀,马腾腾,魏继红. 肾炎康复片联合激素治疗儿童紫癜性肾炎的临床疗效及安全性分析[J]. 医学研究与教育, 2019, 36(2): 28-32.
[5]	陈兰玉,吴银玲,谷钇蔚,陈彬,李孟鑫,陶美慧,朱梦梦,葛少钦. 化积健脾汤对肥胖导致雄性小鼠生殖功能损伤的治疗效果[J]. 医学研究与教育, 2019, 36(1): 37-45.
[6]	黄雅琴,夏月平,牛培. 通心络胶囊治疗冠心病心绞痛症状的研究进展[J]. 医学研究与教育, 2016, 33(3): 52-56.
[7]	解素勇，聂津，张建红，王奕芳，邵伟. 利多卡因联合舒芬太尼硬膜外麻醉在急诊剖宫产术中的应用[J]. 医学研究与教育, 2015, 32(6): 37-40.
[8]	冯敏，郄永涛，王岩军，张维娜. 果酸治疗颜面部轻中度痤疮临床疗效观察[J]. 医学研究与教育, 2015, 32(4): 13-16.
[9]	姜旭，王元松，张立英，杨景超，邢丽君，张爱玲，孙文亮. 复荣通脉胶囊治疗糖尿病周围神经病变的临床疗效[J]. 医学研究与教育, 2015, 32(4): 5-9.
[10]	孙菊平，代瑞廷，徐金娥，安迪. 丁苯酞联合尼莫地平对血管性痴呆的疗效观察[J]. 医学研究与教育, 2015, 32(1): 36-39.
[11]	路瑞香,张秋萍,郝斌. 益气养胃汤联合西药治疗慢性萎缩性胃炎60例[J]. 医学研究与教育, 2014, 31(4): 30-33,56.
[12]	马幼菊,马晓莉. 散结镇痛胶囊联合曼月乐治疗子宫腺肌病疗效观察[J]. 医学研究与教育, 2014, 31(4): 16-19.
[13]	王红杰. 腺样体切除治疗小儿分泌性中耳炎疗效观察[J]. 医学研究与教育, 2013, 30(5): 39-41.
[14]	丁亚楠,李春晖,王冀伟,王延滨. 以癫痫为主要症状的颞叶占位病变的手术治疗[J]. 医学研究与教育, 2013, 30(3): 29-32.
[15]	张晓梅,姚亮,高雅丽,刘式浩,董宏伟,牛培. 光疗的基础与临床应用[J]. 医学研究与教育, 2013, 30(3): 1-7.