doi:10.3969/j.issn.1674-490X.2017.01.005

Abstract

Abstract: Objective To understand the poliomyelitis antibody level of healthy population in Baoding city from 2011 to 2015 and evaluate immune effect, so as to provide scientific basis for the control and prevention.Methods The poliomyelitis antibody level of healthy people was detected by neutralization test of the micro cells from each country of Baoding city(contain 23 counties).Results The neutralizing antibody positive rates of I,II,III viruses were 99.83%,99.83% and 100%, respectively, and the geometric mean titer(GMT)were 1︰157.95, 1︰154.34, 1︰149.78.There were no statistical differences forⅠ, Ⅱ, and Ⅲ polio antibody GMT between different age groups and different counties or districts.Conclusion The immunization cold-chain system of Baoding city is being run in good condition and effect of polio vaccine immunization is remarkable.Importantly, a protective barrier had been built against polio in healthy people in Baoding city.

Key words: polio, neutralizing antibody, immune

CLC Number:

R181

References

[1] 梁晓峰.实现无脊髓灰质炎后中国免疫规划工作现况分析[J].中国计划免疫, 2005, 11(5): 333-338.
[2] 崔惠, 唐海淑, 郭强, 等.新疆维吾尔自治区2012年脊髓灰质炎病毒学监测结果和分析[J].中国疫苗和免疫, 2015, 21(1): 29-31.
[3] 马论文.2011~2012年新疆阿合奇县脊髓灰质炎疫苗应急强化免疫效果分析[J].疾病预防控制通报, 2013, 28(2): 78-79.
[4] GNANASHANMUGAM D, TROY S B, MUSINGQINI G, et al.Immunologic response to oral polio vaccine in human immunodeficiency virus-infected and uninfected zimbabwean children[J].Pediatr Infect Dis J, 2012, 31(2): 176-180.DOI:10.1097/INF.0b013e31823faa5f.
[5] KIM H J, HWANG S, LEE S, et al.A national cross-sectional study for poliovirus seroprevalence in the Republic of Korea in 2012: implication for deficiency in immunity to polio among middle-aged people[J].Bmc Infect Dis, 2015, 15: 164.DOI:10.1186/s12879-015-0894-z.
[6] VANCELIK S, GURAKSIN A, AYYILDIZ A, et al.Seroepidemiology of poliovirus antibody among the children in Eastern Turkey[J].Indian J Med Res, 2007, 126(6): 528-533.
[7] TROY S B, KOUIAVSKAIA D, SIIK J, et al.Comparison of the immunogenicity of various booster doses of inactivated polio vaccine delivered intradermally versus intramuscularly to HIV-infected adults[J].J Infect Dis, 2015, 211(12): 1969-1976.DOI:10.1093/infdis/jiu841.
[8] 赵春芳, 王青, 徐佳薇, 等.重庆市2012年健康人群脊髓灰质炎抗体水平监测分析[J].中国疫苗和免疫, 2013, 19(5): 417-443.
[9] NORTON E B, BAUER D L, WELDON W C, et al.The novel adjuvant dmLT promotes dose sparing, mucosal immunity and longevity of antibody responses to the inactivated polio vaccine in a murine model[J].Vaccine, 2015, 33(16): 1909-1915.DOI:10.1016/j.vaccine.2015.02.069.
[10] 刘桂艳, 王丽霞, 常新, 等.吉林省边境地区健康人群脊髓灰质炎中和抗体水平的监测[J].中国疫苗和免疫, 2009, 15(3): 249-250.
[11] NASIR U N, BANDYOPADHYAY A S, MONTAGNANI F, et al.Polio elimination in Nigeria: A review[J].Hum Vacc Immunother, 2016, 12(3): 658-663.DOI:10.1080/21645515.2015.1088617.
[12] 黄利明, 许二萍, 祝水芬, 等.杭州市人群脊髓灰质炎抗体水平监测结果[J].浙江预防医学, 2008, 20(2): 13-18.
[13] YANG C T, SHI H Y, ZHOU J, et al.CpG oligodeoxynucleotides are a potent adjuvant for an inactivated polio vaccine produced from Sabin strains of poliovirus[J].Vaccine, 2009, 27(47): 6558-6563.DOI:10.1016/j.vaccine.2009.08.047.
[14] 马文军, 王涛, 牛桓彩.北京市昌平区健康人群脊髓灰质炎抗体水平分析[J].中国卫生检验杂志, 2013, 23(3): 755-756.
[15] WESTDIJK J, BRUGMANS D, MARTIN J, et al.Characterization and standardization of Sabin based inactivated polio vaccine: Proposal for a new antigen unit for inactivated polio vaccines[J].Vaccine, 2011, 29(18): 3390-3397.DOI:10.1016/j.vaccine.2011.02.08.

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