Abstract: Objective To observe therapeutic effect and metabolism of blood lipid with Ginkgo leaves tablet and olanzapine on schizophrenia.Methods 80 schizophrenics were randomly divided into two groups:single grouptreated with olanzapine alone(15±5)mg/d, combination group on the basis of olanzapine(15±5)mg/d, and with ginkgo leaves tablet 1.2g/d. The treatment lasted for 8 weeks. Before treatment and at the end of the 2nd, 4th and 8th week, the concentrations of triglyceride(TG), the total cholesterol(TC), low density lipoprotein(LDL)and high density lipoprotein(HDL)of the two groups were monitored. Results In the single group, TG, TC and LDL at 4 weeks and 8 weeks were significance higher than those before treatment(P<0.05), the HDL were significance lower than those before treatment(P<0.05). In the combined group, the LDL and HDL had no significant change compared with those before treatment(P>0.05), the TG and TC were significance higher than those before treatment(P<0.05). Interesting, the TG and TC of the combined group were significance lower than the single group at the 8th weeks(P<0.05). Conclusion The patients with schizophrenia who take olanzapine often have the change of blood lipid level in different degrees, and Ginkgo leaves tablet can antagonize the increase of blood lipid, which is better than that of olanzapine alone.

Key words: ginkgo leaves tablets, olanzapine, schizophrenia, blood lipid