Abstract: Objective To investigate the correlation between cervical squamous intraepithelial lesions(SIL)and vaginal microecological changes in postmenopausal women with human papilloma virus(HPV)infection, and to regulate vaginal microecological balance and block postmenopausal women with HPV infection provide evidence for the development of SIL. Methods We collected postmenopausal women who attended the gynecological clinic of Baoding First Central Hospital from April 2018 to April 2019. HPV positive with or without thinprep cytologic test(TCT)was abnormal. Further colposcopy of cervical biopsy was performed, and 122 patients with SIL were diagnosed as the disease group, and 129 patients without SIL were regarded as the normal group. The results of vaginal microecology examination were compared between the two groups. Results The detection rates of bacterial vaginosis(BV)in the disease group and normal group were 32.79% and 12.40%, respectively(P<0.001). Vulvovaginal candidiasis(VVC)were 14.75% and 10.85%, respectively(P>0.050). Vaginal cleanliness III-IV degrees were 68.03% and 46.51%, respectively(P<0.050). A small amounts of lactobacillus were 13.93% and 20.16%, respectively(P>0.050). WBC>10/HPF were 62.30% and 40.31%, respectively(P<0.001). H₂O₂ deficiency were 15.57% and 22.48%, respectively(P>0.050). Leukocyte esterase positive were 36.07% and 17.83%, respectively(P<0.050). Sialidase positive were 19.67% and 6.20%, respectively(P<0.050). Conclusion BV, poor vaginal cleanliness, more white blood cells, leukocyte esterase and sialidase positive may be closely related to the occurrence and development of SIL in postmenopausal women with HPV infection.

Key words: cervical squamous intraepithelial lesion, vaginal microecology, postmenopausal, human papilloma virus infection