doi:10.3969/j.issn.1674-490X.2021.02.003

Abstract

Abstract: Klotho gene was originally thought to be an anti-aging gene.In recent years, its’ anti-inflammatory response, anti-oxidative stress, anti-apoptosis, regulation of tissue autophagy, calcium and phosphorus metabolism and other functions have been gradually discovered.Related studies have shown that Klotho can participate in the occurrence and development of a variety of kidney diseases, among which Klotho is closely related to the diagnosis and treatment of acute kidney injury(AKI), which is expected to become not only a biomarker for early diagnosis of AKI, but also a therapeutic target.This article reviews the research progress of Klotho in the diagnosis and treatment of AKI in detali.

Key words: Klotho, acute kidney injury, anti-inflammatory, antioxidant, resistance to apoptosis, autophagy

CLC Number:

R692.5

References

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