Abstract: Objective To compare the therapeutic effect of oral compound thrombolysis capsules combined with retinal photocoagulation, intravitreal injection ranibizumab and oral compound thrombolysis capsules combined with retinal photocoagulation in the treatment of retinal branch vein occlusion and macular edema. Methods A retrospective analysis was conducted in 42 patients with 42 eyes diagnosed with retinal branch vein occlusion and macular edema, and the patients were divided into two groups according to different treatment regimens: the experimental group(21 eyes)was treated with intravitreal injection ranibizumab combined with compound oral thrombolysis capsules and retinal photocoagulation, the control group(21 eyes)was given the compound thrombolysis capsule combined with retinal laser photocoagulation, the experimental group received ranibizumab intravitreal injection, while oral thrombolysis capsule, and retinal laser photocoagulation was performed 3 months later. The two groups underwent simple retinal photocoagulation and oral thrombosis capsules. The optimal corrected visual acuity of the two groups was examined during the 6-month treatment period, the changes of macular foveal retinal thickness were determined.Results After 6 months of treatment, the optimal corrected visual acuity of both groups was improved, and the treating effects of the experimental group was better than that of the control group, and the ophthalmic optical coherence tomography showed that the macular foveal thickness was reduced by 415.51 μm(61.45%)in the combination treatment group and 120.51 μm(27.40%)in the control group, which indicated that the treating effects of the experimental group was better than that of the controls. Conclusion Intravitreal injection of ranibizumab combined with oral compound thrombolysis capsule and retinal photocoagulation is safe and effective in the treatment of retinal branch vein occlusion and macular edema.

Key words: ranibizumab injections, compound thrombolysis capsule, retinal photocoagulation, retinal vein embolism, macular edema