Abstract: Acute myocardial infarction, as the most severe condition of coronary artery disease, is often accompanied by severe chest pain, which not only reduces the patient's treatment compliance, but also worsens the condition by increasing myocardial oxygen consumption, increasing cardiac load, and inducing coronary vasospasm. Therefore, timely intervention of severe chest pain is essential in the treatment of acute myocardial infarction. This article reviews the mechanism of pain in acute myocardial infarction, the use of opioids and non-steroidal anti-inflammatory drugs in acute myocardial infarction.

Key words: acute myocardial infarction, opioids, non-steroidal anti-inflammatory drugs, pain, myocardial protection, antiplatelet

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