Irisin: a novel myokine regulating ferroptosis and pyroptosis

doi:10.3969/j.issn.1674-490X.2026.04.002

Abstract

Abstract: Irisin is a novel myokine primarily secreted by skeletal muscle, exhibiting multiple biological functions including the induction of white adipose tissue browning, maintenance of glucose and lipid homeostasis, and bone protection. Irisin is also involved in regulating the pathological processes of various diseases, with particular attention drawn to its role in programmed cell death. Ferroptosis and pyroptosis are two emerging forms of programmed cell death, characterized by iron-dependent lipid peroxidation and inflammasome activation respectively, and are closely associated with the onset and progression of metabolic diseases, inflammatory injuries, and tumors. This article systematically reviews the role and molecular mechanisms of irisin in regulating ferroptosis and pyroptosis under various pathological conditions, including sepsis, diabetes-related diseases, ischemia-reperfusion injury, osteoporosis and cancer. Furthermore, it discusses the prospects and challenges of irisin as a potential therapeutic target, aiming to provide a theoretical basis for future research.

Key words: irisin, programmed cell death, ferroptosis, pyroptosis

CLC Number:

R363
R34

Luo Changqin, Liu Jialin, Fan Liyuan. Irisin: a novel myokine regulating ferroptosis and pyroptosis[J]. Journal of Hebei Medical College for Continuing Education, 2026, 43(4): 14-27.

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