Experimental study of net cliffbean total flavonoids on adjuvant arthritis in rats

Medical Reserch and Education ›› 2014, Vol. 31 ›› Issue (5): 1-4.

Experimental study of net cliffbean total flavonoids on adjuvant arthritis in rats

LIU Yangbin, ZHANG Zhihua

Gannan Medical University, Ganzhou 341000, China

Received:2015-01-16 Revised:2015-01-16 Online:2014-10-25 Published:2014-10-25

Abstract

Abstract: Objective To study the effects of net cliffbean total flavonoids on adjuvant arthritis and its mechanism in rats. Methods Rats model with rheumatoid arthritis were injected freund complete adjuvant, to observe the effects of the high and low dosage of net cliffbean total flavonoids to the chronic paw swelling, nitric oxide(NO) content and glutathione peroxidase (GSH-Px) activity in serum. Results Both net cliffbean total flavonoids groups could reduce the swelling of the model rats, change the level of serum NO, which were lower than that of the model group, whereas the net cliffbean total flavonoids groups could increase the activity of serum GSH-Px. Conclusion Net cliffbean total flavonoids had therapeutic action to rheumatoid arthritis rats, and the mechanism probably was that net cliffbean total flavonoids could strengthen the activity of antioxidase, and scavenge oxygen-free radicals.

Key words: net cliffbean, total flavonoids, adjuvant arthritis, antioxidation

CLC Number:

LIU Yangbin, ZHANG Zhihua. Experimental study of net cliffbean total flavonoids on adjuvant arthritis in rats[J]. Medical Reserch and Education, 2014, 31(5): 1-4.

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