doi:10.3969/j.issn.1674-490X.2017.01.011

Abstract

Abstract: Non-alcoholic fatty liver disease(NAFLD)is one of the most common chronic liver diseases.Although the incidence rate of NAFLD is rising rapidly in our country,effective clinical treatment is still lacking.Due to the close anatomical and functional relationship between the gut and the liver,emerging evidence suggests an important role of gut microbiota in the initiation and progression of NAFLD.Altered gut microbiota due to environmental factors can lead to liver damage.Results of animal studies strongly support the protective effect of probiotics against NAFLD.Currently,there is only a small number of randomized controlled clinical trials evaluating the effectiveness of probiotics on NAFLD treatment;nonetheless,findings show intake of probiotics can improve symptoms of the disease.More multi-centre large-scale randomized controlled trials are needed in order to provide evidence for clinical application of probiotics.

Key words: non-alcoholic fatty liver disease, probiotics, gut microbiota

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References

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