doi:10.3969/j.issn.1674-490X.2019.01.008

Abstract

Abstract: Objective To explore the effect of Huji Jianpi Decoction on weight inhibition and reproductive function injury caused by obesity in male mice with spleen deficiency dampness resistance. Methods An animal model of obesity was established then given treatment with traditional Chinese medicine and western medicine, the body weight was examined. The effects of obesity on reproductive function were evaluated from the aspects mentioned below, weight and histomorphology of testicular and epididymal, and semen parameters such as sperm concentration, sperm viability and sperm motility. The therapeutic effect of Chinese medicine were also measured by the above parameters. Results The weight and wet weight of epididymis in model blank mices were obviously higher than that of normal group and drug group. Compared with the model group, the problem including the testicular moisture and its coefficient, epididymal coefficient and semen parameters decreased, and the phenomenon containing the loose and detached structures of testicle and epididymis were improved in both the Chinese medicine experimental group and orlistat control group. However, the effects of traditional Chinese medicine were outstanding in improving testicular moisture weight and semen parameters. Conclusion Huaji Jianpi Decoction can effectively inhibit the rapid growth of weight and has a certain therapeutic effect on obesity-induced reproductive damage in obese mice.

Key words: Huaji Jianpi Decoction, obese male mice, reproductive impairment, treatment effect

CLC Number:

R242

References

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