doi:10.3969/j.issn.1674-490X.2020.06.002

Abstract

Abstract: Coxsackievirus A group 16 strain(CA16)infection is very common in China. CA16 constantly mutated in the epidemic process, and its pathogenicity is significantly different from enterovirus 71(EV71). CA16 can induce a variety of microRNAs(miRNAs)and affect the transmission of inflammatory signaling pathways, leading to pathological damage. At present, CA16 infection models in mice, tree shrews and macaques have been successfully established, which can be used to evaluate the effect of anti CA16 drugs and vaccines. In terms of detection, multiplex real-time RT-PCR can be used for high-sensitivity detection and rapid typing of HFMD, and colloidal gold immunochromatographic assays can be used for rapid diagnosis. A variety of monovalent and multivalent CA16 vaccines can induce effective immunity in animal experiments.

Key words: Coxsackievirus A group 16 strain, hand, foot and mouth disease, pathogenicity, animal model

CLC Number:

R512.5

References

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