Abstract: Objective To investigate the clinical research of general anesthesia for lower limb operation dezocine preemptive analgesia. Methods 78 cases of lower limb surgery under general anesthesia patients were selected from May, 2013 to May, 2014 in our hospital as the research object, the patients were randomly divided into observation group (40 cases) and control group (38 cases), two group patients were all taken surgery under general anesthesia, the patients of the observation group meanwhile given dezocine preemptive analgesia. The occurrence of pain, analgesia and the adverse reaction of patients after operation were compared between the two groups. Results The postoperative 4 h, VAS in the two groups were not statistically different (P>0.05), and after operation for 6 h, postoperative 12 h and after operation for 24 h, patients in group VAS score were significantly lower than that of the control group, with significant difference (P<0.05), after operation for 4 h, 24 h, two groups of patients sedation score was not significant difference (P>0.05), after operation for 8 h, postoperative 12 h, sedation score of observation group was significantly lower than that of the control group, with statistically significant difference (P<0.05), 10 cases of patients in the observation group occurred adverse reactions (25%), 18 patients in the control group occurred adverse reactions (47.37%), compared with two groups, there was statistically differences (P<0.05). Conclusion Applying dezocine preemptive analgesia in patients with lower extremity anesthesia before the operation are beneficial to the patients to improve pain, relieve patients postoperative sedation and reduce the incidence of adverse reaction operation, which is worthy of clinical application.

Key words: dezocine, preemptive analgesia, lower extremity operation