Abstract: Objective To explore whether the fibrinogen (FIB) level can predict post procedural myocardial injury and clinical prognosis after percutaneous coronary intervention (PCI). Methods FIB level was measured preopratively in patients scheduled to undergo PCI to analyze its predictive value of postoperative myocardial injury. ROC analysis was performed to determine the cutoff point, at which sensitivity and specificity would be maximal. Based on the boundary value, the study subjects were divided into two groups. Compared the incidence of postoperative myocardial injury and cTnI concentration between two groups, and observed if there any differences. Follow-up of 1 year, surveyed if the adverse cardiovascular events had any differences. Results The preoperative FIB level had predictive value for myocardial injury of post-PCI (Area Under Curve, AUC =0.782, P<0.001). FIB boundary value was 3.85 g/L, sensitivity 65.53%, specificity 78.54%. The incidence of myocardial injury had a significant difference between the FIB <3.85 g/L group and FIB≥3.85 g/L group(13.93% VS 52.81%, χ²=36.959, P<0.001). The cTnI levels of postoperative was higher in the FIB≥3.85 g/L group[(0.25±0.67) ng/mL vs (0.55±0.65) ng/mL, t=-3.129, P=0.002]. The incidence of adverse cardiovascular events had statistical differences between the two groups(Log Rank P=0.025). FIB≥3.85 g/L led to a significant increase in adverse cardiovascular events (HR=2.069, 95%CI: 1.056-4.054). Conclusion The preoperative fibrinogen concentration has predictive values on post procedural myocardial injury and clinical outcomes on patients underwent selective PCI.

Key words: fibrinogen, percutaneous coronary intervention, myocardial injury