Abstract: Objective To observe the effects of peony licorice bolus of risperidone with different proportions on female schizophrenia patients suffered hyperprolactinemia induced by risperidone. Methods 120 patients were randomly divided into group A (Risperidone), group B (Peony∶licorice 1∶1, Risperidone), group C (Peony∶ licorice 2∶1, Risperidone). The change of serum levels of prolactin, estradiol, testosterone, follicle stimulating hormone, luteinizing hormone, progesterone were observed before and after treatment for 4, 8 and 12 weeks. Positive and negative symptom scale were used to evaluate the effect of treatment before and after treatment. Adverse drug reactions were evaluated by using the side reaction scale before and after treatment. Results Compared with group B and group C, the serum of prolactin levels of group A were significantly decreased (P<0.05). Compared with group B, the serum of prolactin levels of group C were significantly decreased (P<0.05), which suggested that the serum levels of prolactin in female patients with schizophrenia could be reduced by a greater degree than 2∶1 that of 1∶1. Conclusion The peony and licorice pill can obviously reduce serum prolactin levels of risperidone, but the ratio is 2∶1 to the maximum extent of the serum prolactin levels of the peony and licorice pills.

Key words: different proportions, the peony and licorice pill, risperidone, high prolactin