Table of Content

25 October 2015, Volume 32 Issue 5

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Effects of intravenous immunoglobulin in children with severe hand-foot-mouth disease

MA Shiheng, LI Ming

2015, 32(5):  1-3.  DOI: 10.3969/j.issn.1674-490X.2015.05.001

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Objective To study the effects of intravenous immunoglobulin in children with severe hand-foot-mouth disease (HFMD). Methods The medical records of 59 children with severe hand-foot-mouth disease were reviewed. Children with intravenous immunoglobul in therapy were selected as treatment group,the others as control group. Effects of two groups were compared. Results Pyretolysis time, the skin rash regression time, the nervous system symptoms disappeard time, and hospital stays in treatment group were (4.52±1.41)d, (6.35±1.93)d, (4.06±1.25)d, (9.94±2.14)d, respectively, in control group were (5.78±1.12)d, (8.03±2.74)d, (5.53±1.50)d, (11.31±2.05)d, respectively. They were shorter in treatment group than that in control group (P<0.05). Conclusion Intravenous immunoglobulin was safe and effective in children with severe hand-foot-mouth disease.

Application value of PACS image system in the diagnosis of single bone lesions

WU Songhong, CAO Yanxia, LI Xiaodong, DONG Xi, TIAN Yan

2015, 32(5):  4-9.  DOI: 10.3969/j.issn.1674-490X.2015.05.002

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Objective To explore the evaluation of PACS image system in the qualitative diagnosis of single bone lesions. Methods 141 patients with single bone lesion were selected from 6 127 patients who were performed radionuclide bone imaging, underwent CT scan immediately after bone scan, radionuclide bone imaging diagnosis, CT diagnosis respectively, and examined with the combination diagnosis in PACS image system, The final diagnosis was proved by clinical follow-up or pathology. Results Seventy-five patients in 141 cases were diagnosed bone metastases. The diagnostic sensitivity of radionuclide bone imaging, CT and the combination diagnosis in PACS image system were 93.33%(70/75), 85.33%(64/75) and 100%(75/75) respectively. The specifcities were 56.06%(37/66), 98.48%(65/66) and 95.45%(63/66) respectively. The accuracy rates were 75.89%(107/141), 91.49%(129/141) and 97.87%(138/141) respectively. The positive predictive values were 70.71%(70/99), 98.46%(64/65) and 92.15%(75/78) respectively. The negative predictive values were 88.10%(37/42), 85.53%(65/76) and 100%(63/63) respectively. Radionuclide bone imaging was superior to CT scan, CT scan was superior to bone scan in specificity, accuracy and the positive predictive value(P<0.05). There were significant differences in specificity, accuracy and the positive predictive value between the combination diagnosis in PACS image system and bone scan (P<0.05), and in sensitivity and the negative predictive value between CT combined bone scan in PACS image system and CT alone (P<0.05). Conclusion Radionuclide bone imaging has high sensitivity, it has the "navigation" function for CT scan. CT contributes to distinguishing benign and malignant single bone lesions with bone scan. The combination of CT and bone scan can improve accordance obviously in diagnosis of solitary bone metastasis.

Clinical value of transbronehial needle aspiration in the diagnosis of mediastinal occupied lesions

YANG Zexi, ZHANG Zeming, AN Lei, LI Xiangyun

2015, 32(5):  10-13.  DOI: 10.3969/j.issn.1674-490X.2015.05.003

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Objective Objective To evaluate the value of transbronehial needle aspiration(TBNA)in the diagnosis of mediastinal occupied lesions. Methods A retrospective study was conducted in 68 consecutive patients with mediastinal occupied lesions. The patients underwent TBNA by using a flexible bronchoscope from July 2013 to October 2014. Results In all patients, the diagnostic rate was 32.35% by routine bronchoscopy(22/68), and TBNA achieved definitive diagnoses in 57 patients (83.82%). The sensitivity, specificity, accuracy of TBNA in distinguishing malignant mediastinal lesions were 95.45%(42/44), 62.5%(15/24) and 83.82%(57/68) respectively. EBUS was well tolerated by all of the patients, and 2 patients showed bleeding a little at the puncture site, who did not need special treatment. Conclusion With the rapid developments of new technology, the TBNA of mediastinal occupied lesions is still a minimally invasive and safe diagnostic technique.

Clinical curative observation of butylphthalide injection combined with edaravone in the treatment of acute progressive cerebral ischemic stroke

LIU Xiyan, LI Huimin, ZHANG Qincong

2015, 32(5):  14-17.  DOI: 10.3969/j.issn.1674-490X.2015.05.004

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Objective To investigate the clinical effects of butylphthalide injection combined with edaravone in the treatment of progressive cerebral ischemic stroke. Methods 90 patients with progressive cerebral ischemic stroke were divided randomly into three groups, 30 patients in each group. Patients in conventional group were given conventional treatment of ischemic cerebrovascular disease. Patients in control group were treated with edaravone on the basis of conventional treatment. Patients in observed group were given butylphthalide and edaravone on the basis of conventional treatment additionally. The three groups were treated continuously for 14 days. The degree of neurological deficit score (NIHSS) and daily life ability score (Barthel index) were compared respectively among the three groups just before and after treatment. Meanwhile compared the clinical effects and adverse reactions among the three groups.Results Both NIHSS and BI of the three groups were improved following the 14d treatment (F=7.652, 14.102, P<0.01), and the observation group was significantly better than the conventional group and the control group. The difference was statistically significant (P<0.05). The total efficiency of the observation group was 86.67%, which was obviously better than that of the conventional group(43.33%) and the control group (60.00%), the difference was statistically significant (H=12.243, P=0.002). No obvious adverse reaction occurred in the three groups.Conclusion Butylphthalide injection combined with edaravone in the treatment of progressive cerebral ischemic stroke can effectively alleviate nerve function damage, improve the ability of the patients’ daily life, which has higher clinical curative effects and less adverse reactions, is worth popularizing in clinical practices.

Application of multislice CT reconstruction technique in the treatment of joint trauma

GENG Dehai, WANG Qiang, ZHENG Xiaozhou, CHEN Hongbo

2015, 32(5):  18-21.  DOI: 10.3969/j.issn.1674-490X.2015.05.005

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Objective To study and summarize the clinical effects and the practical significance with multislice CT reconstruction technology in treating joint trauma. Methods 93 cases with injured ankle fracture treated in our hospital from March 2010-March 2015 were selected as experimental subjects. All patients were diagnosed with imaging examination as ankle fractures. All the subjects were undergone roentgenoscopy and CT three-dimensional reconstruction examination, the classification evaluation of the 2 approaches and the surgical diagnosis coincidence rate, postoperative recovery quality and internal fixation of quality score were compared. Results The results showed that the coincidence rate of CT three-dimensional reconstruction confirmed cases with surgery was higher than that of roentgenoscopy, Kappa value, sensitivity and specificity of CT three-dimensional reconstruction were superior to roentgenoscopy technique. Before turning outreach, outside pronation and supination out type tests, CT three dimensional reconstruction detection anatomy reset was higher than that of roentgenoscopy technique (P<0.05), type out in front of the spin and spin after spin type tests, suitable internal fixation determined with CT three dimensional reconstruction detection was higher than that of roentgenoscopy technique (P<0.05). Conclusion The application value of multislice CT reconstruction technology in examining joint trauma is high, which can accurately determine fracture type, surgical approach and treatment plan.

Clinical effects of alpha hydroxy acid combined with collagen dressing in the treatment of facial acne

FENG Min, QIE Yongtao, WANG Yanjun, ZHANG Weina

2015, 32(5):  22-25.  DOI: 10.3969/j.issn.1674-490X.2015.05.006

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Objective To investigate the efficacy of alpha hydroxy acid combined with collagen dressing in the treatment of facialacne. Methods Sixty-six patients with acne were randomly divided into treatment group (alpha hydroxy acid combined with collagen dressing) and control group(alpha hydroxy acid only). Alpha hydroxy acid were applied to the patients for two months once every two weeks. Collagen dressing were treated afteralpha hydroxy acid on treatment group once a day during the first week and once every two days during the second week. Results The effective rates in the treatment group and the control group were 87.88% and 51.52% respectively, which had statistically significance between the two groups. Conclusion Alpha hydroxy acid combined with collagen dressingforfacial acne is safely and effectively, and has a certain effects on skin aging repair such as dry skin and fine wrinkle which can improve the life quality of patients. It has prospects of clinical distribution.

Clinical estimation of different concentration of mytomycin C in treating in patients with II-III styles chronic suppurative sinusitis

GAO Yongping, LIU Huiqing, MA Jinying, RAN Cheng, DU Jinduo

2015, 32(5):  26-28.  DOI: 10.3969/j.issn.1674-490X.2015.05.007

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Objective To assess the efficacy of different concentration mitomycin C (MMC) in treating patients with II-III styles chronic suppurative sinusitis to find out an effective method for using MMC. Methods 420 cases with II-III styles chronic suppurative sinusitis were randomized to group A and group B. The patients in group A were used 0.2 g/L MMC in operation, group B used 0.4 g/L MMC in operation. All patients had follow-up study with the time of 18-30 months(20.5±1.02 months) postoperatively. Results In group A,186 cases were cured,the cure rate was 88.6%, nasal cavity adhesion were 24 cases,invalid rate was 11.4%. In group B, 202 cases were cured,the cure rate was 96.2%, nasal cavity adhesion were 8 cases, invalid rate was 3.8%. Conclusion Intraoperative MMC seems to be a safe and effective procedure and can decrease nasal cavity adhesion.

Analysis on traditional Chinese medicine’s medication rule in prescriptions for the primary thrombocytosis based on data mining

LI Yuan, LIU Panying, LI Haibin, LI Tao

2015, 32(5):  29-34.  DOI: 10.3969/j.issn.1674-490X.2015.05.008

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Objective To explore the traditional Chinese medicine for primary thrombocytosis evidence. Methods Collect the medical record of TCM treatment of primary thrombocytosis, based on the data mining software , such as frequency analysis,the rules of using the software integration analysis, improved mutual information method, the complex system entropy and entropy of unsupervised clustering hierarchy clustering data mining methods were used to analyze TCM syndromes and herbs for the treatment of primary thrombocytosis. Results Based on the 57 selected medical records, the appearance frequency of symptoms, treatment and the frequency of each herb and association rules among the herbs were computed, 35 core combinations and 6 new prescriptions were also mined from the database. Conclusion Chinese medicine has been accumulated experiences in the treatment of primary thrombocytosis and has rules to follow, mainly for the blood stasis syndrome differentiation of syndrome, blood heat, something the effect such as clear heat, cooling blood, invigorating the circulation,which has strong regularity.

Effects of peony licorice bolus of risperidone with different proportions on female schizophrenia patients suffered hyperprolactinemia

XIE Shanshan, DING Liang, CHEN Yaqing

2015, 32(5):  35-38.  DOI: 10.3969/j.issn.1674-490X.2015.05.009

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Objective To observe the effects of peony licorice bolus of risperidone with different proportions on female schizophrenia patients suffered hyperprolactinemia induced by risperidone. Methods 120 patients were randomly divided into group A (Risperidone), group B (Peony∶licorice 1∶1, Risperidone), group C (Peony∶ licorice 2∶1, Risperidone). The change of serum levels of prolactin, estradiol, testosterone, follicle stimulating hormone, luteinizing hormone, progesterone were observed before and after treatment for 4, 8 and 12 weeks. Positive and negative symptom scale were used to evaluate the effect of treatment before and after treatment. Adverse drug reactions were evaluated by using the side reaction scale before and after treatment. Results Compared with group B and group C, the serum of prolactin levels of group A were significantly decreased (P<0.05). Compared with group B, the serum of prolactin levels of group C were significantly decreased (P<0.05), which suggested that the serum levels of prolactin in female patients with schizophrenia could be reduced by a greater degree than 2∶1 that of 1∶1. Conclusion The peony and licorice pill can obviously reduce serum prolactin levels of risperidone, but the ratio is 2∶1 to the maximum extent of the serum prolactin levels of the peony and licorice pills.

Analysis on induced abortion among adolescents (Report of 167 cases)

XIE Suyong, NIE Jin, ZHANG Jianhong, WANG Yifang, SHAO Wei, ZHANG Xin, LI Hongliang, SONG Lijuan

2015, 32(5):  39-41.  DOI: 10.3969/j.issn.1674-490X.2015.05.010

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Objective To investigate the effects of sufentanil in relieving postoperative pain on the persons who had received epidural anesthesia. Methods One hundred and twenty ASAⅠ-Ⅱ pregnant women undergoing epidural anesthesia were enrolled in this study. They were divided into 3 groups: The ones who had epidural anesthesia with Sufentanil (group A). The ones who had intravenous anesthesia with Sufentanil in advance (group B) and the ones without any preemptive analgesia (group C). The visual analogue scale (VAS) score, sedation score (Ramsay), and the incidence of postoperative nausea and vomiting were observed respectively at each time point. Results Depending on visual analogue scale (VAS) and score sedation scores (Ramsay) at each time point and the incidence of postoperative nausea and vomiting, the results of group A were better than that of group B and C, the difference had statistical significance (P<0.05). Conclusion Sufentanil can reduce the pain which the person had epidural anesthesia obviously, it can also be good to reduce the incidence of postoperative nausea and vomiting. The patients are satisfied with this approach, which is worthy widely applied in clinical practices.

Observation of influence of radiotherapy and chemotherapy on T Lymphocytes subsets in patients with nasopharyngeal carcinoma

LIU Bin, LIU Lixia, ZANG Aimin, MA Tao, WANG Ping, ZHANG Yonggang

2015, 32(5):  42-45.  DOI: 10.3969/j.issn.1674-490X.2015.05.011

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Objective To explore the relationships between changes of immune functions in patients with nasopharyngeal carcinoma(NPC)pre-chemoradiotherapy and post chemoradiotherapy. Methods The flow cytometry(FACS Calibur) was used to detect the blood T, B Lymphocytes subsets of 60 healthy check-ups and 60 NPC patients before and after chemoradiotherapy. The immune indexes of changes before and after the radiotherapy were analyzed and their test values were compared. Results There were no significant differencesin CD3+, CD16+56+, CD19+(t were 1.567; 0.971; 1.561, P were 0.078; 0.392; 0.240)between the healthy check-ups and the NPC patients before chemoradiotherapy. CD4+, CD4+/CD8+ had a downward trend(t were2.389; 2.358, P were 0.01, 0.01)while CD8+ had an upward trend (t=-2.342, P=0.019), which was statistically significant. CD3+, CD4+, CD4+/CD8+ were significantly different before and after the chemoradiotherapy,CD3+, CD4+, CD4+/CD8+ gradually down, which had significant differences(t were -7.163, -11.217, 3.817 P<0.01); CD8+, CD16+56+ gradually up,which had significant differences(t were -8.271, 4.383, P were 0.010.001).There was no significant difference in CD19+ (t=-0.986, P=0.323). Conclusions The immune functions get lower in the NPC patients after chemoradiotherapy and can be estimated by the test of the blood T, B Lymphocytes subsets.

A multiple linear stepwise regression of risk factors for bad marriage in the elderly

MA Youju, SHI Junrong, WU Xueshan, GU Yonghong, WANG Liwen, ZHANG Xiaoyan, WANG Weiming

2015, 32(5):  46-49.  DOI: 10.3969/j.issn.1674-490X.2015.05.012

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Objective To study the life satisfaction and its risk factors of bad marriage in the elderly for providing references for policy-makers to improve the quality of them. Methods 838 participants over 60 years of age in Baoding were surveyed with the inventory of life satisfaction index A, and the influential factors were studied by the method of multiple linear stepwise regression. Results The percentage of bad marriage in the elderly was 51.8%, and there LSI was lower than the elderly with a good marriage. The main influential factors on life quality of the bad marriage in the elderly were endowment way, social activities, daily consumption source and life self-care ability by the analysis multiple linear stepwise regression. Conclusion The elder people with bad marriage state have higher requirements on the endowment way, social activities, daily consumption source and life self-care ability.

Analysis of the influencing factors of the status of urban and rural residents’ health literacy in Baoding

ZHOU Jinsa, JIA Sinong, LI Dongxue, LIU Meiou, LI Zhiping, LI Cui

2015, 32(5):  50-54.  DOI: 10.3969/j.issn.1674-490X.2015.05.013

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Objective To leam the current situations of residents' health literacy in urban and rural areas in Baoding to offer scientific reference for providing scientific basis for making related policy and strategy. Methods The spot investigation using questionnaire was conducted using the scale of residents having health literacy to collect urban and rural residents ranged from 15 to 79 years old randomly in Baoding by using the multistage sampling method, the influencing factors were evaluated and analyzed. Results We distributed 1020 questionnaires, and recycled 1006 effective questionnaires, the effective recovery rate was 98.63%. The average possession rate of health literacy was 12.10%, the average possession rate of the healthy lifestyle and behavior literacy was the lowest, and accounted for 9.50% respectively among them. Univariate analysis showed that the health literacy was different and the difference was statistically significant in different age, nation, standard of culture, marital status, whether engaged in medical professional, household resident population and average monthly incomes. Logistic regression analysis showed that: The main factors influencing the residents' health literacy were nation, education level and household resident population. The minority cultures are higher than the han nationality in the level of the health literacy, the OR was 5.366. The higher educational level, the higher proportion of health literacy might be, the OR was 1.699. The more of the household resident population, the higher proportion of health literacy might be, the OR was 1.383. Conclusion The urban and rural residents' health literacy rate was low in Baoding, the main factors influencing the residents' health literacy were nation, education level and household resident population, we need to carry out health promotion interventions in this population to improve the level of residents' health literacy.

Analysis on current status of hypertension and its related factors in government functionaries of a large state-owned enterprise

ZONG Keliang, TIAN Lei, LIU Wenyi, GAO Congli, GENG Limei, FANG Huiyong

2015, 32(5):  55-60.  DOI: 10.3969/j.issn.1674-490X.2015.05.014

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Objective To study the prevalence of hypertension in government functionaries of a large state-owned enterprise and discuss its related risk factors to provide basis for comprehensive prevention and control. Methods The government functionaries of this enterprise were investigated with questionnaire and physical examination from Apr. to May 2015, and the related factors of hypertension were analyzed by univariate chi-square test and multivariate logistic regression. Results 576 cases were effectively examined and 104 patients with hypertension were detected with a prevalence rate of 18.06%. Univariate analysis showed the prevalence rate of hypertension was related to gender, age, BMI, central obesity, hypertension family history, dyslipidemia, drinking and daily perturbation salt. Multivariate logistic regression showed that older than 50, male, high BMI,having hypertension family history, high TG, drinking and more daily perturbation salt were risk factors of hypertension. Conclusion The incidence of hypertension is related to multiple factors, and physical examination, health education and health intervention should be enhanced, and its related risk factors should be contraposed for comprehensive prevention and control.

Nursing of sural neurovascular flap in repairing the skin defect of foot and ankle after VSD operation

HAN Cuiyu, DONG Shuxiang, WANG Lingna, REN Haimei, ZHANG Xinrong, SHI Tonghuan

2015, 32(5):  61-63.  DOI: 10.3969/j.issn.1674-490X.2015.05.015

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Objective To investigate the important nursing measures in repairing the retrograde island flap pedicled with the nutrient vessels of the gastrocnemius nerve. Methods 9 cases of ankle skin defect after VSD patients were given psychological nursing by introducing fiap surgery related knowledge, guided postural training, then we gave them close observation of blood supply of the fiap, strengthened the psychological pain nursing and proper in 72 hours after surgery. Results Seven flaps survived, two cases suffered from partial necrosis. Conclusion Preoperative fully preparation, close observation, psychological care, pain management, and rehabilitation are the keys to the success of sural neurovascular pedicle island flap grafting.

Effects of continuous nursing on the functional recovery of patients with breast cancer

QI Juan, XU Yan, LI zhong, zHAO Binyu

2015, 32(5):  64-66.  DOI: 10.3969/j.issn.1674-490X.2015.05.016

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Objective To study the effects of continuity care on functional recovery of patients with breast cancer after operation. Methods The patients with breast cancer who were less than or equal to 70 years old were randomly divided into two groups, the control group and the continuity nursing group. Continuity nursing care was given in continuation nursing group, and routine nursing care was given in the control group. Results Compared with the control group, the functional recovery of shoulder joint, self-care ability and functional training initiative in the continuity nursing group were all improved. Conclusion The patient may timely get correct recovery guide after continuity of care, which contributes to functional recovery of pathological limbs for patient.

Application of QCC management in improving exclusive breastfeeding during hospitalization

WANG Hongyan, ZHANG Ruihong, MA Yajie

2015, 32(5):  67-70.  DOI: 10.3969/j.issn.1674-490X.2015.05.017

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Objective To discuss the application results of obstetric nurses using QCC anagement to solve the problem of the low rate of exclusive breastfeeding. Methods By setting up the QCC team, identifying the main factors affecting the rate of exclusive breastfeeding through retrospective investigation, using brainstorming to propose a solution, continuously improve and form a standardized breastfeeding missionary work mode via circle ability, the exclusive breastfeeding rates were finally increased. Results Exclusive breastfeeding rate of experimental group(maternal and child) was 55%, while in the control group was 38%, the knowledge of breastfeeding in mothers and their family members in the experimental grasp was significantly better than the control group, and the difference was significant( P<0.01). Conclusion QCC activities not only enhance the exclusive breastfeeding rate of maternal and child in hospital, but cultivate the ability to solve problems of the department members and enhance the cohesion of department.

Effects of individualized nursing intervention on the arteriovenous fistula in treating patients with hemodialysis

ZHANG Yajuan

2015, 32(5):  71-73.  DOI: 10.3969/j.issn.1674-490X.2015.05.018

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Objective To investigate the effects of nursing intervention on the arteriovenous fistula in treating patients with maintenance hemodialysis. Methods From April, 2014 to April, 2015, 95 patients with arteriovenous fistula were randomly divided into control group and observation group, 48 cases in control group, 47 cases in control group were treated with nursing intervention. Results In the observation group, the incidence rate of the loss of the arteriovenous fistula, the knowledge awareness, comfort degree of patients, nursing job satisfaction were better than the control group, P<0.05. Conclusion The individualized nursing intervention can reduce the incidence rate of arteriovenous fistula in hemodialysis, increase the patient's satisfaction with nursing work and improve the quality of life of patients.

Advances on Y-box binding protein 1’s functions in the tumorigenesis and oncotherapy

QU Penghuan, SHI Jianhong

2015, 32(5):  74-77.  DOI: 10.3969/j.issn.1674-490X.2015.05.019

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Y-box binding protein 1 (YB-1) is a member of the family of DNA-and-RNA-binding proteins, YB-1 participates in a wide variety of DNA/RNA-dependent events, including DNA reparation, pre-mRNA transcription and splicing, regulation of translation, cell proliferation and malignant cell transformation. Studies have demonstraed that abnormal expression of YB-1 has a significant effect on tumorigenesis. Nowadays, YB-1 as targets for cancer therapy has become a hot spot

Mechanism and treatment of encephaledema caused by hemntencephalon

CAO Guohui, WANG Xinping, WENG Peishan

2015, 32(5):  78-84.  DOI: 10.3969/j.issn.1674-490X.2015.05.020

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Hemntencephalon is a common disease that seriously endanger people's physical and mental health, and encephaledema caused by hemntencephalon is the important pathophysiological procedure, which is a material reason for deterioration and death in patients with hemntencephalon. It may significantly improve prognosis if we correctly understand the mechanism, and give the treatment properly as well as promptly.

Discussion on old people’s needs in pension institutions

WANG Shuo, JING Kunjuan

2015, 32(5):  85-89.  DOI: 10.3969/j.issn.1674-490X.2015.05.021

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Pension institutions are an important part of socialization support for the elderly. With the development of aging, pension institutions play an important role in family size shrinking and functional weakening, chronic disease, disability and empty-nest elderly increasing. Based on the framework of Maslow’s hierarchy of needs theory, the authors review old people’s needs in pension institutions at home and abroad, aiming at proving the basis for pension institutions needs assessment in the elderly.

Treating bone erosion of rheumatoid arthritis with “phlegm” and “poison”

ZHAO Jing, GAO Longjuan, LIU zhenhua, CHEN Huangzhen, WANG Shifei, MA Yuchen

2015, 32(5):  90-92.  DOI: 10.3969/j.issn.1674-490X.2015.05.022

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Bone erosion of Rheumatoid arthritis belongs to the theory of bone rheumatism and renal arthralgia of suwen. Bone lesions in rheumatoid arthritis disease confidential in “phlegm”, “poison”, the pathological process that is “phlegm”, “poison” invasion or endogenous, phlegm and toxin accumulation, toxicity and keep help sputum, corrosion of steel corrosion of bone. The treatment of rheumatoid arthritis bone disease with “phlegm” and “poison” is regarded as the primary.

Application of potential of mesenchymal stem cell in the treatment of cancer

JU Hailong, LIANG Lu, BIAN Jianfei, ZHANG Bing

2015, 32(5):  93-97.  DOI: 10.3969/j.issn.1674-490X.2015.05.023

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Stem cell treatments are being increasingly explored for their possible potential to treat various cancers. Mesenchymal stem cells are believed to possess anti-tumor potential and are preferred for their properties like immune privileged nature, ability to migrate to the site of tumor and capability for multilineage differentiation. This tumor tropism property of MSCs could be utilized to deliver anti-tumor biological agents to the site of tumor. In a tumor micro-environment, MSCs are believed to play both, a pro-tumorigenic and an anti-tumorigenic role. However, this is dependent on a host of factors like, types of MSCs, its source, type of cancer cell line under investigation, interactions between MSCs, host’s immune cells and cancer cells. Among several cytokines secreted by MSCs, TRAIL (Tumor necrosis factor related apoptosis inducing ligand) are reported to be pro-apoptotic for tumor cells. Umbilical cord tissue derived MSCs are believed to regulate TRAIL expression in MSC-cancer cell co-culture system resulting in induction of apoptosis in cancer cells. We present a review concerning on pro-tumorigenic and anti-tumorigenic properties of MSCs based on different studies reporting.

“Task driven method” in the application of the Chinese medical information retrieval course study

GAO Luan, LU Xiang, LI Dongnan, SUN Juan

2015, 32(5):  98-101.  DOI: 10.3969/j.issn.1674-490X.2015.05.024

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“Task driven method” was applied to explore the curriculum of Chinese medical information retrieval teaching practices. Firstly the teaching design was optimized, the course was divided into four links such as “proposed tasks-analysis task-to complete the task-summary task”. And the corresponding feedback and assessment mechanism were carried out. The research showed that this teaching mode could improve students' autonomous learning ability and information literacy of Chinese medicine comprehensively.

Discussion on building the harmony doctor-patient relationship from the angle of ethics

GUO Ningyue

2015, 32(5):  102-108.  DOI: 10.3969/j.issn.1674-490X.2015.05.025

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To explore the doctor-patient relationship from the perspective of ethics , we found that it is a special and multi-level relationships, and also a social relationship as well as a moral relationship. Therefore, under the system of the market economy, it is necessary to introduce the ethical dimension in order to build a harmonious doctor-patient relationship. This paper will do an ethical research on the crux of the deterioration of the doctor-patient relationship in China and put forward the ethical countermeasures of building a harmonious doctor- patient relationship.