Abstract: Objective To investigate the early blood drug concentration correlations of acute methamidophos poisoning with T lymphocyte subsets. Methods 92 patients with acute methamidophos pesticide taken orally admitted into Affiliated Hospital of Hebei University between January, 2007 to June, 2013 were selected. According to the degree of poisoning, they were divided into mild, moderate poisoning group (54 cases) and severe poisoning group (38 cases), another 92 healthy people who taken physical check-up as control group. Detection and analysis of the relationship between serum drug concentration and toxic CD3+, CD8+, CD8+CD28+, CD8+CD28-were conducted. Results The concentration of blood drug level of severe poisoning group was significantly higher than that of mild and moderate poisoning group (P<0.01). CD3+, CD8+, CD8+CD28+cell number were decreased signiifcantly than that of mild and moderate poisoning group (P<0.01). but the number of CD8+CD28-cells were significantly increased than that of mild and moderate poisoning group (P<0.01). Conclusion The higher the early blood drug concentration of acute methamidophos poisoning, the degree of poisoning is severer, the more seriously impaired the immune cells are.

Key words: Methamidophos, blood drug concentration, CD8+CD28+, CD8+CD28-