Abstract: Objective To analyze the distribution of pathogens tract and their drug resistance in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD). Methods The sputum samples of 110 AECOPD patients from our hospital and the pathogen species in all samples were tested. The drug sensitivity was determined. Results Of all the pathogens found in AECOPD patients, 50.69% were Gram-negative, 39.33% were epiphytes, 7.87 % were Gram-positive, 33.70% of the patients were co-infected by more than two pathogens. Among the Gram-negative bacilli, the main pathogens included Pseudomonas aeruginosa, Acinetobacter baumannii and Egypt hopes the fungus. Among the Gram-positive cocci, the main pathogens included Staphyloccus aureus and Streptococcus pneumoniae, The results of drug sensitivity test showed that most of the Gram-negative bacilli were more sensitive to imipenem, meropenem, cefepime, ceftazidime,cefoperazone shubatan, pipercillin, pipercillin and tazobactam, levolfoxacin, ciprolfoxacin and aztreonam. The epiphytes were highly sensitive to amphoteric enzyme, lfuconazol, itraconazole and voriconazole, while most of the Gram-positive cocci were more sensitive to vancomycin,linezolid,leicoplanin,cefuroxime,cefotaxime sodium and chloramphenicol. Conclusion Gram-negative bacilli are predominant in lower respiratory tract in AECOPD patients The ratio of mycotic infection and mixed infection are high, to which more attention should be paid. Drug resistance should be considered adequately to be used appropriately.

Key words: AECOPD, pathogen, antimicrobial susceptibility