Protective effects of sevolfurane on CPB related pulmonary injury

doi:10.3969/j.issn.1674-490X.2013.06.004

Abstract

Abstract: Objective To investigate the protective effects of sevoflurane on pulmonary injury in patients suffered valvulopathy after cardiopulmonary bypass(CPB). Methods Forty patients were randomly divided into four groups:control group(group C), evolfurane group(group S1, group S2, group S3). The patients of group C were only treated with intravenous anesthetics; 0.5MAC, 1.0MAC, 1.5MAC sevoflurane were inhalated in group S1,S2,S3 after CPB. Patients in all groups were the same in premedication, anesthetic induction, maintenance of anesthesia before and during CPB, method of cardiopulmonary bypass. PaO2, PaCO2, VT, FiO2, A-aDO2, OI ,Cdyn, Cstat were measured before induction of anesthesia (T0) , before CPB(T1), at the discontinuation of CPB(T2), at the end of operation(T3), 2 h(T4), 4 h(T5), 8 h(T6), 12 h(T7), 24 h(T8) after operation. Results Compared with group C, the pulmonary oxygenation function of patients in group S1,S2,S3 was better respectively after operation(P<0.05);the compliance of pulmonary was raised respectively(P<0.05). Conclusion Sevolfurane inhalated anesthesia can reduce lung injury in patients after cardiopulmonary bypass, and its lung protection is related to the amount of sevolfurane positively.

Key words: sevolfurane, cardiopulmonary bypass, lung protection

CLC Number:

WU Guangyi,LI Yongle,WU Yi. Protective effects of sevolfurane on CPB related pulmonary injury[J]. Medical Reserch and Education, 2013, 30(6): 17-21.

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