doi:10.3969/j.issn.1674-490X.2020.06.003

Abstract

Abstract: Acute respiratory distress syndrome is one of the most common diseases in ICU with a mortality rate of 46%. Mechanical ventilation as a key supporting treatment is helpful to improve the oxygenation of the affected lung. Improper setting of ventilator parameters or overexertion of spontaneous breathing may increase the risk of ventilator-induced lung injury, accelerate the deterioration of the disease, and increase the fatality rate. In recent years, research on ventilator-induced lung injury has been conducted, and the currently recognized classical mechanisms include barotrauma, volume injury, shear injury, and biological injury. Researchers have tried to quantify or even quantify the factors that contribute to lung injury. Until 2016, Gattinoni et al. proposed the concept of calculating mechanical power and calculation formula for the first time in combination with the respiratory motion equation, bringing new research direction for quantifying lung injury. How to combine the concept of mechanical power to develop the best lung protection ventilation strategy has once again become a research hotspot. The research on mechanical power is still in the initial stage. Now, the optimal ventilation mode and lung protection strategy will be analyzed from the derivation process of mechanical power equation and the influence of various load factors on mechanical power.

Key words: acute respiratory distress syndrome, mechanical ventilation, ventilator-induced lung injury, mechanical power, lung protection ventilation strategy

CLC Number:

R332.1

References

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