Abstract: Objective To observe the clinical curative effects and security of mizolastine combined with traditional Chinese medicine(Yupingfengsan) in the treatment of chronic urticaria. Methods 120 patients of chronic urticaria were divided into 2 groups randomly. The experimental group had 62 patients while the control group had 58 patients. The patients in experimental group took mizolastine 10 mg/d and Yupingfengsan 1 dose/d twice a day. The control group took mizolastine 10mg/d only. The two groups were treated continuously for four weeks together. The clinical curative effects were appraised according to the clinical symptoms and physical decline index before and after the treatment at 1st, 2nd week and 4th week. Results The effective rates were 91.93%and 70.69%respectively in the experimental group and the controls. There was a signiifcant difference between the two groups(P<0.01). Conclusion Mizolastine combined with traditional Chinese medicine(Yupingfensan) is quite effective in the treatment of chronic urticaria, with less side effects, high cure rate and low recurrence.

Key words: mizolastine, Yupingfengsan, chronic urticaria