Abstract: Objective To investigate the clinical effect and safety when Mizolastine was combined with the capsule of Runzaozhiyang to cure the chronic urticarial. Methods The 110 cases were divided into two groups, one was the observation group, Mizolastine and the capsule of Runzaozhiyang were taken orally by the patients from the observation group, and the dose was 10mg once a daily and 4 capsules one time, 3 times per day for Mizolastine and the capsule of Runzaozhiyang, respectively. The other group was the check, 54 cases were only fed with the Mizolastine, the usage and dose was same as that of test group. The observation lasted for 4 weeks continuously and the effect was evaluated based on the clinical symptoms, the decrease exponent of physical sign after one week, two weeks, and four weeks. Results The cure rate in observation group was 92.86%, and the control group was 74.07%. The difference was signiifcant (P<0.05). Conclusion The therapy of Mizolastine combined with the capsule of Runzaozhiyang to cure the chronic urticarial can get a better curative effects and this therapy has a little side-effects and good compliance.

Key words: Mizolastine, capsule of Runzaozhiyang, chronic urticaria