Abstract: Objective To investigate the effects of Sodium Fusidate on detections of serium total blile acid(TBA). Methods Serium TBA was detected by using the circulating enzymatic method. Distilled water was treated as a control, the amount of TBA was analyzed in different solutions as follows:in serium;in the mixture of Sodium Fusidate and distilled water and in its different concentrations respectively; and in the mixture of Sodium Fusidate and serium and in its different concentrations respectively. Each solution was analyzed triplicatedly. Results The average Serium TBA was 4.4 μmol/L. However, the average amount of TBA in the mixture of Sodium Fusidate and distilled water and in its dilutions of 2, 4, 8, 16 times were 226.53, 130.42, 77.12, 40.78, 21.47 μmol/L respectively. Correspondendly, the average results of Sodium Fusidate serium mixture and its 2, 4, 8, 16 times dilutions were 233.17, 138.82, 85.47, 47.91, 25.58 μmol/L respectively. Conclusion The assays desmontrate that Sodium Fusidate could severely affect the detection of serium TBA and give rise to signiifcant increases. Therefore, it is suggested that those patients who need to know their liver functions should stop taking Sodium Fusidate before doing the tests.

Key words: sodium fusidate, total blile acid, circulating enzymatic method