Abstract: Objective To know the impact of comprehensive intervention in iodine deficiency disorders in school-age children. Methods Taking the consumption of iodized salt, oral iodized oil pills, multisectoral collaboration, start-up of thyroid clinics, systematic management of iodine deficiency disorders, surveillance and epidemiological investigation, focusing on intervention, extensive health education etc method of comprehensive interventions to investigate the goiter prevalence changes. Results The goiter rate of the school-age children who had not the special intervention was 23.40%in 1993, which was higher than the national standard. After iodine intervention, the goiter rate gradually decreased to 5.01% in 1997, which was close to the national standards. After comprehensive intervention, the goiter rate was always controlled within 5% from 1998 to 2011. Comparing the goiter rate after comprehensive intervention and before intervention, as well as the goiter rate after comprehensive intervention and after intervention, the differences were both statistically significant (Ρ<0.001). Conclusion Iodine deficiency disorders interventions can reduce the goiter prevalence in Yixian, achieving the goal of eliminating iodine deficiency.

Key words: iodine deficiency disorders, comprehensive intervention, school-age children, goiter rate