Abstract: “Yinyang and Wuxing” theories are the characteristics of Traditional Chinese Medicine(TCM), however, they are also the major hindrances impeding people to understand and accept TCM. Actually, "Yinyang" theory had been widely adopted to describe the positive and negative feedack mechanisms in biomedical research. In this paper, the author proposed that the “Wuxing theory” may also be explained using scientific language. If we looked “Wuxing” in TCM theory as five most fundamental and primary functions, instead of internal organs, we could understand TCM theory better on the point of modern sciences. Movever, "Yinyang and Wuxing” theory may help researchers to understand the essential pathogenesis of disease better, and prompt the modern medical research development to an integral direction.

Key words: Yinyang, Wuxing, Zangfu theory, traditional Chinese medicine, biomedical research