Abstract: Objective To investigate the effects of intravenous immunoglobulin(IVIG)combined with methylprednisolone in the treatment of phase 2 hand-foot-mouth disease(HFMD). Methods 108 cases with phase 2 HFMD admitted into Affiliated Hospital of Hebei University from July 2013 to December 2016 were selected and treated with mannite and ribavirin in vein as basic therapy, while 48 cases(observation group)received IVIG combined with methylprednisolone. Results The duration of fever, rash, and the central nervous system(CNS)involvement were shorter in the observation group than that in the control group(P<0.05). After treatment, the percentage of neutrophils, the levels of serum NSE, S100B, IL-6, IL-10 and TNF-α in the observation group were significantly lower than those in the control group. There was a better overall curative rate in the observation group than that in the control group(P<0.05). Conclusion IVIG combined with methylprednisolone regimen can result in a recovery of NSE, S100B. It can be helpful to shorten the sick course, improve the curative effects and the immunity function.

Key words: hand foot and mouth disease, neuron specific enolase, S100B, intravenous immunoglobulin, methylprednisolone, cytokines