Developments of S100B protein in perinatal medicine

doi:10.3969/j.issn.1674-490X.2013.04.019

Abstract

Abstract: The fundamental diagnostic procedures of perinatal brain injury determined by domestic and foreign scholars are based on the clinical manifestations, cerebral ultrasound, dynamic electroencephalogram monitoring, cerebrospinal lfuid examination, cerebral CT, MRI and doppler ultrasound. However, these methods mentioned above have some shortcomings, such as inconvenience, complexity, poor dynamic monitoring, high medical cost, late for ifnding the brain injury, et.al, which often result in slow diagnosis and treatment. However, the S100B protein coming from the brain itself, as the direct predictive factors of cell injury in nervous system, have some advantages, such as high sensitivity, easy operation, good reproducibility, easy dynamic monitoring, et.al. Furthermore, it can quantitatively observe the brain injury. The paper introduces the biological characteristics, detection methods of S100B protein and the recent developments of its applications in perinatal medicine.

Key words: S100B protein, gestational age, fetal growth restriction, neonatal hypoxic ischemic encephalopathy

CLC Number:

R715

LONG Aiyun,WENG Zhanping. Developments of S100B protein in perinatal medicine[J]. Medical Reserch and Education, 2013, 30(4): 75-79.

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