Abstract: Objective To optimize the preparation process of telmisartan sodium salt in telmisartan tablets. Methods The effect of different production processes on the dissolution profile of telmisartan sodium salt prepared by different drying processes was studied. Results The dissolution profiles of telmisartan sodium salt prepared by vacuum drying and spray drying were different. Different telmisartan sodium salt drying processes had an effect on the dissolution rate of the formulation. Conclusion The telmisartan tablets prepared by spray-dried telmisartan sodium salt are similar to the reference preparations. The capsule has a feasible process, good repeatability and stable and reliable quality.

Key words: telmisartan sodium salt, spray drying, solvent