doi:10.3969/j.issn.1674-490X.2020.04.001

Abstract

Abstract: The SIRT family is an evolutionarily conserved family of NAD⁺-dependent lysine deacetylases and ADP ribose transferases that regulate cell physiological activity. NAD⁺ levels are dynamically changed in the physiological activities of cells, whose abnormal changes can cause various diseases. SIRT has cell-specific and organelle-specific expressions in the brain and is involved in the pathology of many diseases, including ischemic stroke. Therefore, the development and use of SIRT-specific modulators might exhibit neuroprotection effects and is expected to develop a new target for the treatment of ischemic stroke.

Key words: ischemic stroke, sirtuins, NAD⁺

CLC Number:

R743.3

References

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