Abstract: Objective To investigate the effect of parecoxib sodium alone or in combination with dexmedetomidine in preventing emergence agitation(emergence agitation, EA)in patients undergoing closed abdominal injury surgery and its influence on inflammatory factors. Methods 125 patients with closed abdominal injury underwent open surgery under general anesthesia were selected, they were divided into parecoxib sodium combined with dextropyrimidine group(PD group,41 cases), parecoxib sodium group(P group, 45 cases)and saline group(C group, 39 cases). The subjects in the PD group, P group, C group were injected with dexmedetomidine+parecoxib sodium, parecoxib sodium and equal saline 30 minutes before the end of operation respectively. The incidence of EA, recovery time of breathing, recovery time, extubation time, hemodynamic parameters and inflammatory factorslevel were observed. Results(1)The incidence of EA in PD group, P group was significantly lower than that in C group, Ramsay sedation score in PD group was significantly higher than that in P group, C group, Riker sedation and restlessness score and PARD score were significantly lower than those in P group, C group.(2)There was no significant difference in respiratory recovery time, recovery time and extubation time among the three groups.(3)At T1 and T2, MAP and HR in PD group, P groups were significantly lower than those in C group.(4)Serum TNF-1α and IL-6 levels in PD group, P groups at T1 and T2 were significantly lower than those in C group, and IL-10 levels were significantly higher than those in C group. Conclusion During general anesthesia for closed abdominal injury, parecoxib sodium alone or in combination with dexmedetomidine can prevent EA, respiratory recovery, recovery time and extubation time have not been significantly prolonged, hemodynamic parameters are stable and inflammation reaction has been inhibited. And the effects of combined use are better than that of single use.

Key words: parecoxib sodium, dexmedetomidine, emergence agitation, closed abdominal injury, inflammatory factors