doi:10.3969/j.issn.1674-490X.2021.03.005

Abstract

Abstract: Objective To investigate the relationship between serum vitamin D levels in pregnant women and early pregnancy-related diseases, including bacterial vaginosis and spontaneous abortion.Methods A total of 60 women with early spontaneous abortion who were admitted to Baoding NO.1 Central Hospital were selected as the early spontaneous abortion group.A total of 50 early pregnancy women with bacterial vaginosis were enrolled as the bacterial vaginosis group.And 80 cases of healthy early pregnant women during the same period were collected as normal control group.Peripheral blood samples of all subjects were collected to detect the content of 25-hydroxyvitamin D in serum, and the deficiency rate of vitamin D in each group was analyzed and compared.Results The levels of vitamin D in the early spontaneous abortion group and the bacterial vaginosis group was significantly higher than those in the control group, and the differences were statistically significant(P<0.05).The vitamin D deficiency rate of early spontaneous abortion group(43.33%)was significantly higher than that of normal control group(22.50%), with statistical significance among the two groups(χ²=6.905, P=0.009).The vitamin D deficiency rate in the bacterial vaginosis group(42.00%)was significantly higher than that in the normal control group(22.50%), and the difference between groups was statistically significant(χ²=5.571, P=0.018).Conclusion Pregnant women with serum vitamin D deficiency may be more prone to early spontaneous abortion, and vitamin D deficiency in early pregnancy may also increase the risk of bacterial vaginosis infection.

Key words: pregnantwoman, vitamin D deficiency, spontaneous abortion, early pregnancy, bacterialvaginosis

CLC Number:

References

[1] SONG H B, XU Y, YANG X W, et al.High prevalence of vitamin D deficiency in pregnant women and its relationship with adverse pregnancy outcomes in Guizhou, China[J].J Int Med Res, 2018, 46(11): 4500-4505.DOI: 10.1177/0300060518781477.
[2] 李响,吴效科.维生素D与母体妊娠相关疾病关系的研究进展[J].国际妇产科学杂志,2019,46(6):632-635.
[3] 张素洁, 居漪, 李卿, 等.健康人群血清25-羟基维生素D水平分析[J].检验医学, 2020, 35(10): 1028-1031.DOI: 10.3969/j.issn.1673-8640.2020.10.014.
[4] 自然流产诊治中国专家共识编写组.自然流产诊治中国专家共识(2020年版)[J].中国实用妇科与产科杂志, 2020, 36(11): 1082-1090.DOI: 10.19538/j.fk2020110113.
[5] 谢幸, 孔北华, 段涛.妇产科学[M].9版.北京: 人民卫生出版社, 2018: 70.
[6] 张萌萌, 张秀珍, 邓伟民, 等.骨代谢生化指标临床应用专家共识(2019)[J].中国骨质疏松杂志, 2019, 25(10): 1357-1372.DOI: 10.3969/j.issn.1006-7108.2019.10.001.
[7] 夏维波, 章振林, 林华, 等.维生素D及其类似物临床应用共识[J].中华骨质疏松和骨矿盐疾病杂志, 2018, 11(1): 1-19.DOI: 10.3969/j.issn.1674-2591.2018.01.001.
[8] SCHRÖDER-HEURICH B, SPRINGER C J P, VON VERSEN-HÖYNCK F.Vitamin D effects on the immune system from periconception through pregnancy[J].Nutrients, 2020, 12(5): E1432.DOI: 10.3390/nu12051432.
[9] 万彦伶, 郝翠芳.维生素D与女性生殖激素及妊娠结局关系的研究进展[J].生殖医学杂志, 2018, 27(12): 1255-1259.DOI: 10.3969/j.issn.1004-3845.2018.12.019.
[10] 陈燕媚,周继昌.维生素D对免疫系统作用机制的研究进展[J].营养学报, 2020, 42(3): 301-307.DOI: 10.13325/j.cnki.acta.nutr.sin.2020.03.018.
[11] SHARIF K, SHARIF Y, WATAD A, et al.Vitamin D, autoimmunity and recurrent pregnancy loss: More than an association[J].Am J Reprod Immunol, 2018, 80(3): e12991.DOI: 10.1111/aji.12991.
[12] AKOH C C, PRESSMAN E K, COOPER E, et al.Low vitamin D is associated with infections and proinflammatory cytokines during pregnancy[J].Reprod Sci, 2018, 25(3): 414-423.DOI: 10.1177/1933719117715124.
[13] SAREBANI Z, ALIMORADI Z, AALI E, et al.Investigating the effect of vitamin D vaginal suppository on sexual function among postmenopausal women: study protocol for a randomized controlled trial[J].BMC Womens Health, 2020, 20(1): 27.DOI: 10.1186/s12905-020-00899-6.
[14] 李星烁, 王颖梅, 薛凤霞.维生素D与细菌性阴道病关系研究进展[J].中国实用妇科与产科杂志, 2019, 35(4): 482-485.DOI: 10.19538/j.fk2019040126.
[15] 李仁燕, 杨学妞,李练兵, 等.维生素D在复发性流产中的免疫作用机制与研究进展[J].中国计划生育学杂志, 2019, 27(3): 400-403, 408.DOI: 10.3969/j.issn.1004-8189.2019.03.035.
[16] JEFFERSON K K, PARIKH H I, GARCIA E M, et al.Relationship between vitamin D status and the vaginal microbiome during pregnancy[J].Perinatol,2019, 39(6): 824-836.DOI: 10.1038/s41372-019-0343-8.
[17] 周浒, 王晨曦.212例孕妇维生素D水平及妊娠结局分析[J].中国计划生育学杂志, 2019, 27(2): 237-240.DOI: 10.3969/j.issn.1004-8189.2019.02.025.

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	. [J]. Journal of Hebei Medical College for Continuing Education, 2023, 40(2): 1-9.
[2]	. [J]. Journal of Hebei Medical College for Continuing Education, 2021, 38(1): 23-31.
[3]	. [J]. Journal of Hebei Medical College for Continuing Education, 2020, 37(3): 44-49.
[4]	. [J]. Medical Reserch and Education, 2019, 36(4): 5-9.
[5]	. [J]. Medical Reserch and Education, 2019, 36(4): 19-23.
[6]	. [J]. Medical Reserch and Education, 2018, 35(4): 19-23.
[7]	. [J]. Medical Reserch and Education, 2018, 35(3): 6-19.
[8]	CHANG Yaqing,KONG Hongfang,WANG Fengnuan,XIN Hong. Advances on the study of the relationship between hypothyroidism and infertility [J]. Medical Reserch and Education, 2016, 33(5): 53-58.
[9]	WANG Hongyan,ZHANG Ruihong,ZHU Minjing. Study on application of clinical nursing path form to prevent and treat postpartum hemorrhage in puerperal women [J]. Medical Reserch and Education, 2016, 33(3): 38-41.
[10]	. [J]. Medical Reserch and Education, 2016, 33(3): 73-76.
[11]	ZHOU Liang, HAN Yuanyuan, LUO Jingmei, CHEN Yicheng, FENG Keqing, DU Luanying1, WU Xiaoling. Investigation on the correlation of genital mycoplasma infection with bacterial vaginal in Chengde area [J]. Medical Reserch and Education, 2015, 32(6): 61-64.
[12]	LI Hongmei, LIANG Dongli, PAN Xiumin, GAO Yanjun, MU Yinjing. Medical nursing of 23 patients with straddle injury treated with urethral realignment under endoscopic [J]. Medical Reserch and Education, 2015, 32(6): 72-74.
[13]	XU Xiaoning, CUI Yakun, LU Zhiru. Study on phloroglucin combined with estradiol valerate for postmenopausal embedded IUDs removal operation [J]. Medical Reserch and Education, 2015, 32(3): 48-51.
[14]	SHEN Yan. Blood rheology changes during hysteroscopic resection of submucous uterine fibroids [J]. Medical Reserch and Education, 2015, 32(2): 54-57.
[15]	ZHANG Xiaoju, LU Zhiru. Analysis on induced abortion among adolescents (Report of 167 cases) [J]. Medical Reserch and Education, 2015, 32(2): 44-46.