扶正活血清热方对急性放射性肠炎血清中CAT和MDA的影响

doi:10.3969/j.issn.1674-490X.2013.05.001

医学研究与教育 ›› 2013, Vol. 30 ›› Issue (5): 1-3,7.DOI: 10.3969/j.issn.1674-490X.2013.05.001

• 基础研究 • 下一篇

扶正活血清热方对急性放射性肠炎血清中CAT和MDA的影响

何静¹,赵占学²,张荣贞²,段斐²,杨永滨²

1.河北大学基础医学院，河北保定 071000; 保定市南市区妇幼保健院妇产科，河北保定 071000
2.河北大学基础医学院,河北保定,071000

出版日期:2013-10-25 发布日期:2013-10-25
基金资助:
河北省2010年科技支撑计划项目(102761101)；河北省中医药管理局科学技术研究课题

Effects of Fuzhenghuoxueqingrefang on CAT and MDA in the serum of acute radiation enteritis in rats

HE Jing¹,ZHAO Zhanxue²,ZHANG Rongzhen²,DUAN Fei²,YANG Yongbin²

Online:2013-10-25 Published:2013-10-25

摘要/Abstract

摘要： 目的：探讨扶正活血清热方治疗大鼠急性放射性肠炎（ARE）的作用机制。方法将32只受试大鼠随机分为4组（8只/组），即空白对照组、模型组、地塞米松组、扶正活血清热方组。模型组、地塞米松组和扶正活血清热方组大鼠于成功造模后第2天开始分别用生理盐水、地塞米松和扶正活血清热方灌肠干预5 d（5毫升/只），于照射后第7天,麻醉后大鼠经采血测定其中过氧化氢酶（CAT）的活性和丙二醛（MDA）的含量。结果空白对照组、地塞米松组和扶正活血清热方组血清中CAT活性明显高于模型组（F=23.79，P<0.01）。空白对照组、地塞米松组和扶正活血清热方组血清中MDA含量均明显低于模型组（F=36.41，P<0.01）。结论扶正活血清热方可能通过下调受损组织中脂质过氧化反应程度来治疗放射性肠炎。

关键词: 扶正活血清热方, 放射性肠炎, 过氧化氢酶, 丙二醛

Abstract: Objective To investigate the treating mechanism of Fuzhenghuoxueqingrefang on acute radiation enteritis(ARE)in rats. Methods Thirty two Wistar male rats were randomly divided into 4 groups(8 rats each group), which were composed of blank control, model, dexamethasone, and Fuzhenghuoxueqingrefang groups. The physiological saline, dexamethasone and Fuzhenghuoxueqingrefang were administrated separately at the ifrst day after abdominal irradiation by daily rectal clysma for 5 days. All the rats were anesthetized and the serum activity of peroxidase (CAT) and contents of malonic aldehyde(MDA) were detected at the seventh day after abdominal irradiation separately. Results The activity of serum CAT in the blank control, dexamethasone and Fuzhenghuoxueqingrefang groups were obviously higher than that of the model group(F=23.79, P<0.01). The content of serum MDA in the blank control, dexamethasone and Fuzhenghuoxueqingrefang groups were signiifcantly lower than that of the model groups(F=36.41, P<0.01). Conclusion Fuzhenghuoxueqingrefang could treat ARE in rats by down-regulating the lipid peroxidation in the damaged tissue.

Key words: Fuzhenghuoxueqingrefang, acute radiation enteritis, CAT, MDA

中图分类号:

R363

何静,赵占学,张荣贞,段斐,杨永滨. 扶正活血清热方对急性放射性肠炎血清中CAT和MDA的影响[J]. 医学研究与教育, 2013, 30(5): 1-3,7.

HE Jing,ZHAO Zhanxue,ZHANG Rongzhen,DUAN Fei,YANG Yongbin. Effects of Fuzhenghuoxueqingrefang on CAT and MDA in the serum of acute radiation enteritis in rats[J]. Medical Reserch and Education, 2013, 30(5): 1-3,7.

扶正活血清热方对急性放射性肠炎血清中CAT和MDA的影响

Effects of Fuzhenghuoxueqingrefang on CAT and MDA in the serum of acute radiation enteritis in rats

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