关键词: 抗结核FDC, 板式组合药, 初治肺结核, 转归, 对比分析

Abstract: Objective To get the clinical comparative observation on outcomes of antituberculosis fixed-dose combination and plate combination drug with initial tuberculosis treatment, providing a scientiifc basis for the antituberculosis fixed-dose combination clinical application. Methods Patients with initial treatment tuberculosis were divided into treatment group and the control group. The treatment group was treated with anti tuberculosis ifxed-dose combination, while the control group was treated with plate combination drug. Two groups all used the alternate day therapy program (2H3R3Z3E3/4H3R3). Observe the treatment completion, loss, program change and discontinuation of the medicine of the two groups with the method of control study. Results For the tuberculosis patients of initial treatment smear-positive and initial treatment smear-negative, the treatment completion rate of antituberculosis ifxed-dose combination group was greater than that of plate combination drug group(P<0.05). Loss rate of antituberculosis fixed-dose combination group was less than that of plate combination drug group(P<0.05). Program change rate of antituberculosis ifxed-dose combination group was less than that of plate combination drug group(P<0.05). The rate and the frequency of discontinuation of the medicine of antituberculosis ifxed-dose combination group was less than that of plate combination drug group(P<0.05). Conclusion Antituberculosis fixed-dose combination is advantageous to help medical staff on patient therapy management and supervision, and the application of it in the National Tuberculosis control programme is feasible.

Key words: antituberculosis fixed-dose combination, plate combination drug, initial tuberculosis treatment, outcome, comparative analysis