医学研究与教育 ›› 2015, Vol. 32 ›› Issue (5): 26-28.DOI: 10.3969/j.issn.1674-490X.2015.05.007

• 临床研究 • 上一篇    下一篇

不同浓度丝裂霉素 C 对Ⅱ-Ⅲ型鼻窦炎术后疗效的影响

高永平,刘会清,马金莹,冉程,杜锦朵   

  1. 河北大学附属医院耳鼻喉科,河北 保定 071000
  • 出版日期:2015-10-25 发布日期:2015-10-25
  • 通讯作者: 刘会清(1978—),男,河北保定人,副主任医师,主要从事耳鼻咽喉头颈外科肿瘤研究。E-mail: 13722222902@163.
  • 作者简介:高永平(1964—),男,河北保定人,主任医师,主要从事耳鼻咽喉头颈外科肿瘤研究。E-mail: gyp1964@sina.com

Clinical estimation of different concentration of mytomycin C in treating in patients with II-III styles chronic suppurative sinusitis

GAO Yongping, LIU Huiqing, MA Jinying, RAN Cheng, DU Jinduo   

  1. Department of ENT, Affiliated Hospital of Hebei University,Baoding 071000,China
  • Online:2015-10-25 Published:2015-10-25

摘要: 目的 通过观察在Ⅱ-Ⅲ型鼻窦炎患者手术中应用不同浓度丝裂霉素 C 后鼻腔粘连情况,从而寻找一种安全有效的丝裂霉素 C 应用方案。方法 选择慢性鼻窦炎Ⅱ-Ⅲ型患者随机分成 A 组、B 组行鼻内镜手术 420 例。A 组应用 0.2 g/L 丝裂霉素 C 210 例,B 组应用 0.4 g/L 丝裂霉素 C 210 例。术后定期随访 18~30 个月,平均 (20.5±1.02) 个月。结果 A 组治愈186 例,治愈率为 88.6%,鼻腔粘连 24 例,无效率11.4%;B 组治愈 202 例,治愈率为 96.2%,鼻腔粘连 8 例,无效率3.8%。2 组治愈率差异有统计学意义。结论 鼻腔手术中局部应用 0.4 g/L 丝裂霉素 C 能明显减少术后鼻腔粘连,提高手术疗效。

关键词: 丝裂霉素 C, 鼻腔粘连, 慢性鼻窦炎

Abstract: Objective To assess the efficacy of different concentration mitomycin C (MMC) in treating patients with II-III styles chronic suppurative sinusitis to find out an effective method for using MMC. Methods 420 cases with II-III styles chronic suppurative sinusitis were randomized to group A and group B. The patients in group A were used 0.2 g/L MMC in operation, group B used 0.4 g/L MMC in operation. All patients had follow-up study with the time of 18-30 months(20.5±1.02 months) postoperatively. Results In group A,186 cases were cured,the cure rate was 88.6%, nasal cavity adhesion were 24 cases,invalid rate was 11.4%. In group B, 202 cases were cured,the cure rate was 96.2%, nasal cavity adhesion were 8 cases, invalid rate was 3.8%. Conclusion Intraoperative MMC seems to be a safe and effective procedure and can decrease nasal cavity adhesion.

Key words: mitomycin C (MMC), nasal cavity adhesion, chronic suppurative sinusitis

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