芍药甘草丸对精神分裂症患者高催乳素血症的影响

doi:10.3969/j.issn.1674-490X.2015.05.009

医学研究与教育 ›› 2015, Vol. 32 ›› Issue (5): 35-38.DOI: 10.3969/j.issn.1674-490X.2015.05.009

芍药甘草丸对精神分裂症患者高催乳素血症的影响

谢姗姗^1,2，丁良¹，陈亚青³

1. 河北大学，河北保定 071000；2. 河北省精神卫生中心，河北保定 071000；3. 河北大学附属医院，河北保定 071000

出版日期:2015-10-25 发布日期:2015-10-25
通讯作者: 丁良（1961—），女，天津人，教授，博士，硕士生导师，主要从事药理学研究。E-mail: dingliangzi@aliyun.com
作者简介:谢姗姗（1981—），女，河北衡水人，主治医师，主要从事精神疾病及精神药理学研究。E-mail: 13722257575@126.com

Effects of peony licorice bolus of risperidone with different proportions on female schizophrenia patients suffered hyperprolactinemia

XIE Shanshan^1,2, DING Liang¹, CHEN Yaqing³

1. Hehei University, Baoding 071000,China; 2.Mental Health Center of Hebei Province,Baoding 071000,China; 3.Affiliated Hospital of Hebei University, Baoding 071000,China

Online:2015-10-25 Published:2015-10-25

摘要/Abstract

摘要： 目的观察不同配比的芍药甘草丸对利培酮所致女性精神分裂症患者血清催乳素的影响。方法 120 例患者随机分为A 组 40 例（利培酮）、B 组 40 例（芍药∶甘草＝ 1∶1，利培酮）、C 组 40 例（芍药∶甘草＝ 2∶1，利培酮），观察治疗前、治疗4 周、治疗 8周、治疗12 周后3 组患者血清催乳素水平变化，采用阳性与阴性症状量表（PANSS）评定治疗前后效果，采用副反应量表（TESS）评定治疗前后药物不良反应。结果治疗4 周、8 周、12 周后，B 组、C 组与A 组患者比较，血清催乳素水平均明显下（P<0.05），C 组与 B 组患者比较，血清催乳素水平均明显下降（P<0.05）。提示芍药甘草丸（芍药∶甘草＝ 2∶1）相对于芍药甘草丸（芍药∶甘草＝ 1∶1）可以更大程度地降低女性精神分裂症患者血清催乳素水平。结论芍药甘草丸能降低抗精神病药利培酮所致女性精神分裂症患者血清催乳素水平，但芍药甘草丸尤以 2∶1的配比能最大程度地降低血清催乳素水平，且不影响抗精神病药利培酮的临床疗效。

关键词: 不同配比, 芍药甘草丸, 利培酮, 高催乳素血症

Abstract: Objective To observe the effects of peony licorice bolus of risperidone with different proportions on female schizophrenia patients suffered hyperprolactinemia induced by risperidone. Methods 120 patients were randomly divided into group A (Risperidone), group B (Peony∶licorice 1∶1, Risperidone), group C (Peony∶ licorice 2∶1, Risperidone). The change of serum levels of prolactin, estradiol, testosterone, follicle stimulating hormone, luteinizing hormone, progesterone were observed before and after treatment for 4, 8 and 12 weeks. Positive and negative symptom scale were used to evaluate the effect of treatment before and after treatment. Adverse drug reactions were evaluated by using the side reaction scale before and after treatment. Results Compared with group B and group C, the serum of prolactin levels of group A were significantly decreased (P<0.05). Compared with group B, the serum of prolactin levels of group C were significantly decreased (P<0.05), which suggested that the serum levels of prolactin in female patients with schizophrenia could be reduced by a greater degree than 2∶1 that of 1∶1. Conclusion The peony and licorice pill can obviously reduce serum prolactin levels of risperidone, but the ratio is 2∶1 to the maximum extent of the serum prolactin levels of the peony and licorice pills.

Key words: different proportions, the peony and licorice pill, risperidone, high prolactin

中图分类号:

R964

谢姗姗，丁良，陈亚青. 芍药甘草丸对精神分裂症患者高催乳素血症的影响[J]. 医学研究与教育, 2015, 32(5): 35-38.

XIE Shanshan, DING Liang, CHEN Yaqing. Effects of peony licorice bolus of risperidone with different proportions on female schizophrenia patients suffered hyperprolactinemia[J]. Medical Reserch and Education, 2015, 32(5): 35-38.

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[2]	于丽燕 ,丁良 ,李玉欣. 乌鸡白凤丸与阿立哌唑治疗利培酮所致女性精神分裂症患者高催乳素血症的对照研究[J]. 医学研究与教育, 2015, 32(4): 20-23.

芍药甘草丸对精神分裂症患者高催乳素血症的影响

Effects of peony licorice bolus of risperidone with different proportions on female schizophrenia patients suffered hyperprolactinemia

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